dermal cells

[Acta Pharmacologica Sinica] Researchers examined the ability of three different G-protein-coupled receptor (GPCR) agonists to reverse signaling inhibition and ameliorate rash induced by epidermal growth factor receptor inhibitors (EGFRi).

[Tissue Engineering Part C-Methods] Keratinocytes, fibroblasts, melanocytes, and mesenchymal stem cells (MSCs) are promising cell sources for cell spray procedures. Scientists focus on the different types of cells and spray instruments used in cell delivery procedures.

[Molecular Carcinogenesis] Researchers reported that the Rho-associated protein kinase (ROCK) signaling pathway was a critical regulator of oncogene-induced senescence in skin carcinogenesis.

[Journal of Investigative Dermatology] Stimulator of IFN genes (STING) is a universal receptor that recognizes cytosolic DNA and triggers innate immune activation. Investigators elucidated the role of STING in the inflammation during psoriasis.

[Stem Cells Translational Medicine] Scientists tested the efficacy of the MSC secretome in a physiologically relevant ex vivo equine skin biofilm explant model and explored the impact of the MSC secretome on the antimicrobial defense mechanisms of resident skin cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that in atopic dermatitis, IL-4 and IL-13 stimulated the expression of 3β-hydroxysteroid dehydrogenase 1, a key rate-limiting enzyme in sex steroid hormone synthesis, predominantly expressed by sebaceous glands in human skin.