Interleukins 4 and 13 Drive Lipid Abnormalities in Skin Cells through Regulation of Sex Steroid Hormone Synthesis

By
Justin.choi
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0
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Scientists showed that in atopic dermatitis, IL-4 and IL-13 stimulated the expression of 3β-hydroxysteroid dehydrogenase 1, a key rate-limiting enzyme in sex steroid hormone synthesis, predominantly expressed by sebaceous glands in human skin.
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract