embryonic stem cells

[Experimental and Molecular Medicine] Investigators showed that O-GlcNAcylation of Sox2 at threonine 258 regulated mouse ESC self-renewal and early cell fate.

[Chemosphere] The authors summarize the effects of nanomaterials on the proliferation and differentiation of ESCs, mesenchymal stem cells and neural stem cells.

[Stem Cell Research & Therapy] The authors observed if transplantation of superparamagnetic iron oxide nanoparticle-labeled human ESCs could migrate in the neural degenerated area and improve motor dysfunction in an AAV2-Htt171-82Q transfected Huntington rat model.

[Genome Research] To test whether diploidization resulted from aberrant DNA replication, the authors profiled DNA replication timing in isogenic haploid and diploid ESCs.

[Biochemical Journal] Researchers employed quantitative proteomic profiling to identify proteins whose expression was regulated by the ERK5 pathway in mouse ESCs (mESCs), revealing a function for ERK5 signaling in regulating dynamically expressed early embryonic 2-cell stage genes including the mESC rejuvenation factor ZSCAN4.

[Scientific Reports] Researchers provided a proof-of-concept that human embryonic stem cell-derived neurons could integrate and modulate the activity of a human host neuronal network.