An ERK5-KLF2 Signaling Module Regulates Early Embryonic Gene Expression and Telomere Rejuvenation in Stem Cells

Researchers employed quantitative proteomic profiling to identify proteins whose expression was regulated by the ERK5 pathway in mouse ESCs (mESCs), revealing a function for ERK5 signaling in regulating dynamically expressed early embryonic 2-cell stage genes including the mESC rejuvenation factor ZSCAN4.