embryonic stem cells

[Cell Reports] The authors demonstrated that β-transducin repeat-containing protein (β-TrCP) targeted Tfcp2l1 for ubiquitination and degradation in a mitogen-activated protein kinase-activated protein kinase 2 (MK2)-dependent manner.

[Cell and Tissue Research] Investigators established a cell line of human ESCs stably expressing GFP-α-tubulin and mCherry-H2B by lentiviral infection to analyze and visualize mitosis in detail.

[Nature Communications] Destabilization of CTCF and cohesin binding correlated with altered transcription and accelerated differentiation. This association was conserved in ESCs.

[Genes & Development] Researchers described an integrated genome-scale loss- and gain-of-function screening approach to identify genetic networks governing ESC proliferation and differentiation into the three germ layers.

[Stem Cell International] The authors investigated how human iPSCs (hiPSCs) overcame hyperosmotic stress compared to a cell line that did not harbor pluripotent characteristics and found possible implications of microtubule organization on the response to hyperosmotic stress in hiPSCs.

[Nature Communications] Using a computational framework based on Gaussian processes and fractional Brownian motion, the authors showed that average chromatin diffusion properties were surprisingly similar in interphase and mitosis in mouse ESCs.