MK2 Promotes Tfcp2l1 Degradation via β-TrCP Ubiquitin Ligase to Regulate Mouse Embryonic Stem Cell Self-Renewal

The authors demonstrated that β-transducin repeat-containing protein (β-TrCP) targeted Tfcp2l1 for ubiquitination and degradation in a mitogen-activated protein kinase-activated protein kinase 2 (MK2)-dependent manner.