embryonic stem cells

[Nature Communications] Scientists performed transcriptomic analysis on wild-type and Importin-13-knockout mouse ESCs, revealing enrichment of differentially expressed genes involved in stress responses and apoptosis regulation.

[Scientific Reports] Researchers showed that mouse ESCs that lacked or overexpressed haspin, albeit prone to chromosome misalignment during metaphase, could still divide, expand and differentiate.

[Life Science Alliance] The authors used Resf1 knockout cell lines to determine the requirements of RESF1 for ESC self-renewal and for in vitro specification of ESCs into primordial germ cell-like cells

[Cell Death Discovery] Researchers showed that the transcripts of Gadd45 family genes, including Gadd45a, Gadd45b, and Gadd45g, were gradually increased upon mouse ESC differentiation. Upregulation of Gadd45 members decreased cell proliferation and induced endodermal and trophectodermal lineages.

[Stem Cell Reviews and Reports] The impact of 3D co-culture of human fetal pancreatic-derived mesenchymal cells with human embryonic stem cell-derived pancreatic progenitors development towards endocrine and beta cells was assessed.

[iScience] Potential interactors of epithelial cell adhesion molecule (EpCAM) were identified in murine F9 teratoma cells using a SILAC-based proteomic approach. Endocytosis and membrane recycling were means of regulation of EpCAM protein levels during differentiation of ESCs and epithelial-to-mesenchymal transition induction in carcinoma cells.