embryonic stem cells

[Frontiers in Cell and Developmental Biology] Research developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.

[Science] Scientists used screens to identify a compound, 5′-iodo-2′-deoxyuridine, that increased gene expression noise in mouse ESCs in culture without changing the overall rate of transcription of most genes.

[Cell Reports] To determine whether SAGA and ATAC had redundant or specific functions, investigators compared the effects of histone acetyltransferase inactivation in each complex with that of inactivation of either SAGA or ATAC core subunits in mouse ESCs.

[Nature Communications] Transcriptional profiling and in vitro assays using human melanoma cells demonstrated that SALL4 loss induced a phenotype switch and the acquisition of an invasive phenotype.

[eLife] Investigators established conditions to differentiate human PSCs into yolk sac-like cells that resembled the post-implantation human hypoblast molecularly and functionally.

[Development] Investigators reported that the conjunct activity of two orphan nuclear receptors, Esrrb and Nr5a2, paralleled the importance of that of Oct4 and Sox2 in naïve ESCs.