embryonic stem cells

[iScience] Researchers developed a dual SHOX2:GFP; MYH6:mCherry knock-in hESC reporter line, which allowed for the identification and purification of sinoatrial node (SAN)-like cells.

[Cell Reports] Scientists found that the depletion of Rif1 broke down the barrier to the transition from ESCs to trophoblast stem cells.

[Cell Reports] To establish a genome-wide loss-of-function screening for heterozygous mutations, the authors fused normal haploid hESCs with a library of mutant haploid hESCs.

[Nature Communications] Investigators reported a replenishable female mESC system, Xmas, that allowed rapid assessment of X chromosome inactivation, the epigenetic silencing mechanism of one of the two X chromosomes that enabled dosage compensation in female mammals.

[Stem Cells and Development] The authors review advances in understanding the impact of forces and mechanics on functions and fate of embryonic stem cells, adult stem cells, and cancer stem cells and the pathways of mechanotransduction in cells.

[Scientific Reports] Scientists showed that the hepatic functions of hPSC-hepatocyte-like cells were facilitated by applying physiological liver temperatures during hepatic differentiation.