endothelial cells

[Bioengineered] Scientists found that in oxidized low-density lipoprotein-treated HUVECs, the increased production of total cholesterol, free cholesterol, and pro-inflammatory cytokines were observed, reversed by 10 μM and 25 μM Nintedanib.

[Cell Death Discovery] The authors unveiled a novel DNA methyltransferase 1-SIRT6 axis that contributed to the regulation of myocardin-related transcription factor A (MRTF-A) acetylation and ICAM-1 transactivation in endothelial cells.

[Hypertension] Investigators found endothelial DKK1 expression was upregulated in serum and lung tissues obtained from patients with pulmonary hypertension (PH), mice with hypoxia-induced PH, and human pulmonary artery endothelial cells cultured under hypoxic conditions.

[Journal of Ethnopharmacology] Shuxuetong injection promoted angiogenesis and improved function recovery in hindlimb ischemia mice by regulation of VEGF-A/platelet-derived growth factor.

[Molecular and Cellular Endocrinology] The authors investigated if ghrelin pretreatment enhanced the protective effect of bone marrow-derived mesenchymal stem cells-conditioned medium on lipopolysaccharide-induced endothelial cell injury.

[FEBS Journal] The authors summarize recent evidence that modulation of the early secretory pathway has great impact on the biogenesis and release of Weibel-Palade bodies.