SIRT6 Mediates MRTF-A Deacetylation in Vascular Endothelial Cells to Antagonize oxLDL-Induced ICAM-1 Transcription

The authors unveiled a novel DNA methyltransferase 1-SIRT6 axis that contributed to the regulation of myocardin-related transcription factor A (MRTF-A) acetylation and ICAM-1 transactivation in endothelial cells.