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endothelial cells

Oxidative Pentose Phosphate Pathway Controls Vascular Mural Cell Coverage by Regulating Extracellular Matrix Composition

[Nature Metabolism] The authors demonstrated that endothelial cell metabolism regulated blood vessel maturation by controlling vascular matrix composition and vascular mural cell recruitment.

Extracellular Vimentin Is an Attachment Factor That Facilitates SARS-CoV-2 Entry into Human Endothelial Cells

[Proceedings of the National Academy of Sciences of the United States of America] The authors described the identification of vimentin, an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells.

Heterogeneity in Endothelial Cells and Widespread Venous Arterialization during Early Vascular Development in Mammals

[Cell Research] Scientists constructed the single-cell transcriptomic landscape of vascular endothelial cells during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos.

Extracellular Vesicles from Adipose-Derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery in a Mouse Model of Transient Middle Cerebral Artery Occlusion

[Current Stem Cell Research & Therapy] The authors explored the contribution of miRNAs in adipose-derived stem cell-extracellular vesicles to the treatment of cerebral ischemia.

Characterization of the COPD Alveolar Niche Using Single-Cell RNA Sequencing

[Nature Communications] The authors analyzed single-cell RNA sequencing profiles of explanted lung tissue from subjects with advanced COPD or control lungs and identified a subpopulation of alveolar epithelial type II cells with transcriptional evidence for aberrant cellular metabolism and reduced cellular stress tolerance in COPD.

Overexpression of the SARS-CoV-2 Receptor Angiotensin Converting Enzyme 2 in Cardiomyocytes of Failing Hearts

[Scientific Reports] Scientists examined the expression of ACE2 in normal hearts and hearts from patients with terminal heart failure.

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