endothelial cells

[Scientific Reports] Researchers investigated the role of endothelial-derived extracellular microRNA-92a in promoting arterial stiffness by regulating endothelial cells –vascular smooth muscle cell communication.

[Nature Protocols] The authors described an in vitro model of the human blood–brain barrier self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes.

[Experimental and Molecular Medicine] Investigators found that CU06-1004, as a vascular leakage blocker, could improve cardiac function by inhibiting cardiac microvascular endothelial cells' hyperpermeability and subsequently reducing the neutrophil’s plugging and infiltration in infarcted hearts.

[Blood] The authors address the vasculopathy of COVID-19 with a focus on the role of the endothelium in orchestrating the systemic response to SARS-CoV-2 infection.

[Cell] Researchers identified highly activated, CD16+ T cells with increased cytotoxic functions in severe COVID-19.

[Cell Reports] A single intravenous administration of mixture of nanoparticles and plasmid DNA expressing Cas9 controlled by CDH5 promoter and guide RNA induced highly efficient genome editing in endothelial cells of the vasculatures, including lung, heart, aorta, and peripheral vessels in adult mice.