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endothelial cells

SDF-1 Secreted by Mesenchymal Stem Cells Promotes the Migration of Endothelial Progenitor Cells via CXCR4/PI3K/AKT Pathway

[Journal of Molecular Histology] The authors investigated whether stromal cell-derived factor (SDF)-1 secreted by mesenchymal stem cells contributed to endothelial progenitor cell migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases/protein kinase B signaling pathway.

MARCO+ Lymphatic Endothelial Cells Sequester Arthritogenic Alphaviruses to Limit Viremia and Viral Dissemination

[EMBO Journal] Following subcutaneous inoculation, arthritogenic alphavirus particles drained via the lymph and were rapidly captured by MARCO+ lymphatic endothelial cells in the draining lymph node, limiting viral spread to the bloodstream.

Calcium-Channel-Blockers Exhibit Divergent Regulation of Cancer Extravasation through the Mechanical Properties of Cancer Cells and Underlying Vascular Endothelial Cells

[Cell Biochemistry and Biophysics] Researchers examined the role of calcium-channel blocking drugs on mechanics of extravasating cancer cells, choosing two clinically-approved calcium-channel blockers as model antihypertensive drugs to simultaneously target cancer cells and an underlying monolayer of endothelial cells.

Propranolol Inhibits the Angiogenic Capacity of Hemangioma Endothelia via Blocking β-Adrenoceptor in Mast Cell

[Pediatric Research] Hemangioma endothelial cells were co-cultured with propranolol-treated HMC-1s supernatants, and their proliferation and apoptosis were investigated.

Hexokinase 2-Driven Glycolysis in Pericytes Activates Their Contractility Leading to Tumor Blood Vessel Abnormalities

[Nature Communications] The authors developed a method that combines magnetic beads and flow cytometry cell sorting to isolate pericytes from tumors and normal adjacent tissues from patients with non-small cell lung cancer and hepatocellular carcinoma.

Bone Marrow CD73+ Mesenchymal Stem Cells Display Increased Stemness In Vitro and Promote Fracture Healing In Vivo

[Bone Reports] The authors showed that isolated CD73-EGFP+ MSCs displayed more pronounced stemness and stronger in vitro differentiation capacity into the osteogenic lineage compared to CD73-EGFP−MSCs.

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