Calcium-Channel-Blockers Exhibit Divergent Regulation of Cancer Extravasation through the Mechanical Properties of Cancer Cells and Underlying Vascular Endothelial Cells

Researchers examined the role of calcium-channel blocking drugs on mechanics of extravasating cancer cells, choosing two clinically-approved calcium-channel blockers as model antihypertensive drugs to simultaneously target cancer cells and an underlying monolayer of endothelial cells.