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endothelial cells

Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis

[Arteriosclerosis Thrombosis & Vascular Biology] Researchers identified integrin α5β1 as an EC receptor for AGGF1 and a novel AGGF1-mediated signaling pathway of α5β1-FAK-Src-AKT for angiogenesis.

Exosomal OTULIN from M2 Macrophages Promotes the Recovery of Spinal Cord Injuries via Stimulating Wnt/β-Catenin Pathway-Mediated Vascular Regeneration

[Acta Biomaterialia] Researchers determined that M2-Exos could augment the angiogenic activities of spinal cord microvascular endothelial cells in vitro.

Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension

[Circulation Research] In human endothelial cells, a striking correlation was observed between the degree of endothelial cell activation as reflected by intracellular adhesion molecule 1, isoLG-adduct accumulation and intracellular GAS6 levels.

An Unusual Nicotinamide Derivative, 4-Pyridone-3-Carboxamide Ribonucleoside (4PYR), Is a Novel Endothelial Toxin and Oncometabolite

[Experimental & Molecular Medicine] Lung metastasis and endothelial function were analyzed together with blood nucleotides, plasma amino acids, nicotinamide metabolites, and vascular ectoenzymes of nucleotide catabolism.

Role of PDE10A in Vascular Smooth Muscle Cell Hyperplasia and Pathological Vascular Remodeling

[Cardiovascular Research] Intimal hyperplasia is a common feature of vascular remodeling disorders. Accumulation of synthetic smooth muscle cell (SMC)-like cells is the main underlying cause. Researchers investigated the function of PDE10A in smooth muscle cell proliferation and intimal hyperplasia both in vitro and in vivo.

Optimization of Polycaprolactone – Based Nanofiber Matrices for the Cultivation of Corneal Endothelial Cells

[Scientific Reports] Four groups of electrospun nanofibrous scaffolds were compared: polycaprolactone (PCL), PCL/collagen, PCL/gelatin and PCL/chitosan. Each of the scaffolds were tissue-engineered with human corneal endothelial cells and analyzed with regard to their potential application as artificial posterior lamellar grafts.

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