endothelial cells

[Scientific Reports] Scientists targeted Monoacylglycerol lipase (MAGL) in TNBCs, using a potent carbamate-based inhibitor AM9928 with prolonged pharmacodynamic effects. AM9928 blocked TNBC cell adhesion and transmigration across human brain microvascular endothelial cells in 3D co-cultures.

[Science Signaling] With transgenic mice that expressed a dominant-negative mutant of the pore-forming Kir6.1 subunit specifically in brain capillary endothelial cells or pericytes, scientists demonstrated that ATP-sensitive K+ channels were present in both cell types and robustly controlled membrane potential.

[Scientific Reports] The authors investigated whether local delivery of adeno-associated viral (AAV) vectors expressing oxidation-resistant wild type apolipoprotein A1 (apoA1) preserved apoA1 functionality.

[Biofabrication] Scientists developed endothelial cell-laden pro- and anti-angiogenic bioinks, supplemented with bioactive matrix-derived microfibers that were created from type I collagen sponges and cartilage decellularized ECM.

[Nature Communications] To identify the signals responsible for HSC formation, scientists used single cell RNA-sequencing to simultaneously analyze the transcriptional profiles of aorta-gonad-mesonephros region-derived cells transitioning from hemogenic endothelium to HSCs,

[Communications Biology] The authors showed that endothelial-induced astrocytes had upregulated expression of A1 astrocytic genes and exhibited a distinctive ECM remodeling profile.