endothelial cells

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that gene-edited, immune-evasive cell grafts could survive and successfully treat diseases in immunocompetent, fully allogeneic recipients. A mixture of endothelial cells and cardiomyocytes was injected into infarcted mouse hearts, and both cell types orthotopically engrafted in the ischemic areas.

[Experimental & Molecular Medicine] Scientists highlight the distinct contributions of IL-6 signaling to the pathogenesis of several types of cytokine storms and discuss potential therapeutic strategies for the management of cytokine storms, including those associated with sepsis and COVID-19.

[Signal Transduction and Targeted Therapy] Scientists demonstrated that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules, ICAM1 and VCAM1.

[Aging] Scientists investigated the regulatory role of exosomal miR-944 derived from glioma stem cells in glioma progression and angiogenesis.

[Reproductive Sciences] Using a tube formation assay between HTR8/SVneo cells and human umbilical vein endothelial cells, scientists found that Tim-3 pathway blockade inhibits tube formation and reversed by addition of recombinant IL-4 and/or IL-10.

[Biomaterials Science] Through in vitro tests, scientists found that copper-doped bioactive glass enhanced angiogenesis by activating the pro-inflammatory environment and the HIF-1α pathway of human umbilical vein endothelial cells.