Mechanochemical Control of Epidermal Stem Cell Divisions by B-Plexins

Researchers identified a critical requirement of B-plexin transmembrane receptors in the response to crowding-induced mechanical forces during embryonic skin development.
[Nature Communications]
Jiang, C., Javed, A., Kaiser, L., Nava, M. M., Xu, R., Brandt, D. T., Zhao, D., Mayer, B., Fernández-Baldovinos, J., Zhou, L., Höß, C., Sawmynaden, K., Oleksy, A., Matthews, D., Weinstein, L. S., Hahn, H., Gröne, H.-J., Graumann, P. L., Niessen, C. M., … Worzfeld, T. (2021). Mechanochemical control of epidermal stem cell divisions by B-plexins. Nature Communications, 12(1), 1308. https://doi.org/10.1038/s41467-021-21513-9 Cite
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Polycomb Complexes Redundantly Maintain Epidermal Stem Cell Identity during Development

Researchers showed how polycomb repressive complex 1 (PRC1) and PRC2 function as two independent counterparts, thereby providing a repressive safety net that protects and preserves lineage identity.
[Genes & Development]
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Reducing Alcohol and/or Cocaine-Induced Reward and Toxicity via an Epidermal Stem Cell-Based Gene Delivery Platform

The authors showed that expression of the glucagon-like peptide-1 gene delivered by epidermal stem cells attenuated development and reinstatement of alcohol-induced drug-taking and seeking as well as voluntary oral alcohol consumption.
[Molecular Psychiatry]
Kong, Q., Li, Y., Yue, J., Wu, X., & Xu, M. (2021). Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform. Molecular Psychiatry, 1–11. https://doi.org/10.1038/s41380-021-01043-y Cite
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Polycomb Complexes Redundantly Maintain Epidermal Stem Cell Identity during Development

Coablation of polycomb repressive complex 1 (PRC1) and PRC2 in embryonic epidermal progenitors resulted in severe defects in epidermal stratification, a phenotype not observed in the single PRC1-null or PRC2-null epidermis.
[Genes & Development]
Cohen, I., Bar, C., Liu, H., Valdes, V. J., Zhao, D., Galbo, P. M., Silva, J. M., Koseki, H., Zheng, D., & Ezhkova, E. (2021). Polycomb complexes redundantly maintain epidermal stem cell identity during development. Genes & Development. https://doi.org/10.1101/gad.345363.120 Cite
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Both Wnt Signaling and Epidermal Stem Cell-Derived Extracellular Vesicles Are Involved in Epidermal Cell Growth

Functional epidermal three dimensional organoids with polarity were cultured using Wnt3a and the supernatant derived from interfollicular epidermal stem cells and fresh medium in a 1:1 ratio
[Stem Cell Research & Therapy]
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Cellular Heterogeneity and Microenvironmental Control of Skin Cancer

In this review, focusing on the skin, scientists investigate potential key mechanisms that ensure tissue homeostasis despite the presence of mutant cells, as well as critical factors that may nudge the balance from homeostasis to tumor formation.
[Journal of Internal Medicine]
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Type XVII Collagen Interacts with the aPKC‐PAR Complex and Maintains Epidermal Cell Polarity

Investigators uncovered COL17 as a binding partner of the aPKC‐PAR complex, which is a key regulating factor of cell polarity. Immunoprecipitation‐immunoblot assay and protein‐protein binding assay revealed that COL17 interacts with aPKC and PAR3. Type XVII collagen (COL17) deficiency or epidermis‐specific aPKCλ deletion destabilized PAR3 distribution in the epidermis, while aPKCζ knockout did not.
[Experimental Dermatology]
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Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo

Adult scalp dermal progenitor cells and epidermal stem cells together with type I collagen as a scaffold material were used to reconstitute bilayer tissue-engineered skin substitutes in vitro.
[Stem Cell Research & Therapy]
Zhang, Q., Wen, J., Liu, C., Ma, C., Bai, F., Leng, X., Chen, Z., Xie, Z., Mi, J., & Wu, X. (2020). Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo. Stem Cell Research & Therapy, 11(1), 407. https://doi.org/10.1186/s13287-020-01924-z Cite
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Altering MYC Phosphorylation in the Epidermis Increases the Stem Cell Population and Contributes to the Development, Progression, and Metastasis of Squamous Cell Carcinoma

To investigate whether and how altered MYC phosphorylation might affect squamous cell carcinoma development, progression, and metastasis, scienttists generated mice with inducible expression of MYCWT or MYCT58A in the basal layer of the skin epidermis.
[Oncogenesis]
Wang, X., Langer, E. M., Daniel, C. J., Janghorban, M., Wu, V., Wang, X.-J., & Sears, R. C. (2020). Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma. Oncogenesis, 9(9), 1–13. https://doi.org/10.1038/s41389-020-00261-3 Cite
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Human Epidermal Stem Cell Differentiation Is Modulated by Specific Lipid Subspecies

By intersecting lipidomic datasets from suspension-induced differentiation and knockdown keratinocytes, scientists pinpointed candidate bioactive lipid subspecies as differentiation regulators.
[Proceedings of the National Academy of Sciences of the United States of America]
Rudan, M. V., Mishra, A., Klose, C., Eggert, U. S., & Watt, F. M. (2020). Human epidermal stem cell differentiation is modulated by specific lipid subspecies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2011310117 Cite
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Extracellular Serine Controls Epidermal Stem Cell Fate and Tumor Initiation

Researchers revealed extracellular serine as a critical determinant of epidermal stem cell fate and provided insight into how nutrient availability was integrated with stem cell fate decisions during tumor initiation.
[Nature Cell Biology]
Baksh, S. C., Todorova, P. K., Gur-Cohen, S., Hurwitz, B., Ge, Y., Novak, J. S. S., Tierney, M. T., dela Cruz-Racelis, J., Fuchs, E., & Finley, L. W. S. (2020). Extracellular serine controls epidermal stem cell fate and tumour initiation. Nature Cell Biology, 1–12. https://doi.org/10.1038/s41556-020-0525-9 Cite
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