Epidermal Stem Cells Maintain Stemness via a Biomimetic Micro/Nanofiber Scaffold That Promotes Wound Healing by Activating the Notch Signaling Pathway

To inhibit the differentiation of epidermal stem cells (EpSCs) and maintain their stemness, scientists developed an electrospun polycaprolactone + cellulose acetate micro/nanofiber for the culture and transplantation of EpSCs.
[Stem Cell Research & Therapy]
Lin, Z., Zhao, C., Lei, Z., Zhang, Y., Huang, R., Lin, B., Dong, Y., Zhang, H., Li, J., & Li, X. (2021). Epidermal stem cells maintain stemness via a biomimetic micro/nanofiber scaffold that promotes wound healing by activating the Notch signaling pathway. Stem Cell Research & Therapy, 12(1), 341. https://doi.org/10.1186/s13287-021-02418-2 Cite
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Lgr6 Marks Epidermal Stem Cells with a Nerve-Dependent Role in Wound Re-Epithelialization

Scientists demonstrated that Lgr6 marked a regionally restricted population of epidermal stem cells that interacted with nerves and specialized in wound re-epithelialization.
[Cell Stem Cell]
Huang, S., Kuri, P., Aubert, Y., Brewster, M., Li, N., Farrelly, O., Rice, G., Bae, H., Prouty, S., Dentchev, T., Luo, W., Capell, B. C., & Rompolas, P. (2021). Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.05.007 Cite
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Single-Keratinocyte Transcriptomic Analyses Identify Different Clonal Types and Proliferative Potential Mediated by FOXM1 in Human Epidermal Stem Cells

Scientists reported that single-cell transcriptome analysis of primary human epidermal cultures identifies categories of genes clearly distinguishing the different keratinocyte clonal types, which are hierarchically organized along a continuous, mainly linear trajectory showing that stem cells sequentially generate progenitors producing terminally differentiated cells.
[Nature Communications]
Enzo, E., Secone Seconetti, A., Forcato, M., Tenedini, E., Polito, M. P., Sala, I., Carulli, S., Contin, R., Peano, C., Tagliafico, E., Bicciato, S., Bondanza, S., & De Luca, M. (2021). Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells. Nature Communications, 12(1), 2505. https://doi.org/10.1038/s41467-021-22779-9 Cite
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Chemical Conversion of Human Epidermal Stem Cells into Intestinal Goblet Cells for Modeling Mucus-Microbe Interaction and Therapy

The authors generated intestinal goblet cells from human epidermal stem cells with two small molecular inhibitors Repsox and CHIR99021 in the presence of basic fibroblast growth factor and bone morphogenetic protein 4 at high efficiency of conversion for a short time.
[Science Advances]
Zhao, A., Qin, H., Sun, M., Tang, M., Mei, J., Ma, K., & Fu, X. (2021). Chemical conversion of human epidermal stem cells into intestinal goblet cells for modeling mucus-microbe interaction and therapy. Science Advances, 7(16), eabb2213. https://doi.org/10.1126/sciadv.abb2213 Cite
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Mechanochemical Control of Epidermal Stem Cell Divisions by B-Plexins

Researchers identified a critical requirement of B-plexin transmembrane receptors in the response to crowding-induced mechanical forces during embryonic skin development.
[Nature Communications]
Jiang, C., Javed, A., Kaiser, L., Nava, M. M., Xu, R., Brandt, D. T., Zhao, D., Mayer, B., Fernández-Baldovinos, J., Zhou, L., Höß, C., Sawmynaden, K., Oleksy, A., Matthews, D., Weinstein, L. S., Hahn, H., Gröne, H.-J., Graumann, P. L., Niessen, C. M., … Worzfeld, T. (2021). Mechanochemical control of epidermal stem cell divisions by B-plexins. Nature Communications, 12(1), 1308. https://doi.org/10.1038/s41467-021-21513-9 Cite
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Polycomb Complexes Redundantly Maintain Epidermal Stem Cell Identity during Development

Researchers showed how polycomb repressive complex 1 (PRC1) and PRC2 function as two independent counterparts, thereby providing a repressive safety net that protects and preserves lineage identity.
[Genes & Development]
AbstractPress Release
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Reducing Alcohol and/or Cocaine-Induced Reward and Toxicity via an Epidermal Stem Cell-Based Gene Delivery Platform

The authors showed that expression of the glucagon-like peptide-1 gene delivered by epidermal stem cells attenuated development and reinstatement of alcohol-induced drug-taking and seeking as well as voluntary oral alcohol consumption.
[Molecular Psychiatry]
Kong, Q., Li, Y., Yue, J., Wu, X., & Xu, M. (2021). Reducing alcohol and/or cocaine-induced reward and toxicity via an epidermal stem cell-based gene delivery platform. Molecular Psychiatry, 1–11. https://doi.org/10.1038/s41380-021-01043-y Cite
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Polycomb Complexes Redundantly Maintain Epidermal Stem Cell Identity during Development

Coablation of polycomb repressive complex 1 (PRC1) and PRC2 in embryonic epidermal progenitors resulted in severe defects in epidermal stratification, a phenotype not observed in the single PRC1-null or PRC2-null epidermis.
[Genes & Development]
Cohen, I., Bar, C., Liu, H., Valdes, V. J., Zhao, D., Galbo, P. M., Silva, J. M., Koseki, H., Zheng, D., & Ezhkova, E. (2021). Polycomb complexes redundantly maintain epidermal stem cell identity during development. Genes & Development. https://doi.org/10.1101/gad.345363.120 Cite
AbstractPress Release
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Both Wnt Signaling and Epidermal Stem Cell-Derived Extracellular Vesicles Are Involved in Epidermal Cell Growth

Functional epidermal three dimensional organoids with polarity were cultured using Wnt3a and the supernatant derived from interfollicular epidermal stem cells and fresh medium in a 1:1 ratio
[Stem Cell Research & Therapy]
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Cellular Heterogeneity and Microenvironmental Control of Skin Cancer

In this review, focusing on the skin, scientists investigate potential key mechanisms that ensure tissue homeostasis despite the presence of mutant cells, as well as critical factors that may nudge the balance from homeostasis to tumor formation.
[Journal of Internal Medicine]
Lichtenberger, B. M., & Kasper, M. (n.d.). Cellular heterogeneity and microenvironmental control of skin cancer. Journal of Internal Medicine, n/a(n/a). https://doi.org/10.1111/joim.13177 Cite
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Type XVII Collagen Interacts with the aPKC‐PAR Complex and Maintains Epidermal Cell Polarity

Investigators uncovered COL17 as a binding partner of the aPKC‐PAR complex, which is a key regulating factor of cell polarity. Immunoprecipitation‐immunoblot assay and protein‐protein binding assay revealed that COL17 interacts with aPKC and PAR3. Type XVII collagen (COL17) deficiency or epidermis‐specific aPKCλ deletion destabilized PAR3 distribution in the epidermis, while aPKCζ knockout did not.
[Experimental Dermatology]
Watanabe, M., Kosumi, H., Osada, S.-I., Takashima, S., Wang, Y., Nishie, W., Oikawa, T., Hirose, T., Shimizu, H., & Natsuga, K. (n.d.). Type XVII collagen interacts with the aPKC-PAR complex and maintains epidermal cell polarity. Experimental Dermatology, n/a(n/a). https://doi.org/10.1111/exd.14196 Cite
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