The authors review recent findings on Src family kinase (SFK) signalling during intestinal homeostasis, regeneration and tumorigenesis. They also describe the key nongenetic mechanisms underlying SFK tumour activities in colorectal cancer, and discuss how these mechanisms could be exploited in therapeutic strategies to target SFK signalling in metastatic colon cancer.
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Researchers reanalyzed 19 GEO gene expression profiles to identify and annotate colorectal cancer versus normal signatures, single-gene perturbation, and single-drug perturbation signatures.
[npj Systems Biology and Applications]
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Investigators found that lentiviral-mediated knockdown of ATG9A in intestinal epithelial cells prevented epithelial barrier formation by >95% and resulted in significant mislocalization of multiple tight junction proteins.
[Molecular Biology of the Cell]
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Scientists characterized the regional distribution of prostatic cell types in the young intact dog to enable comparisons with human and mice and they examined how the cellular source of procollagen 1A1 changes with age in intact male dogs.
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Delving into the possible mechanisms underlying the crosstalk between COVID-19 and prostate cancer (PCa) alludes a potential association between SARS-CoV-2 targets on host epithelial cells and PCa genetic aberrations and molecular signatures, including AR and TMPRSS2.
[Prostate Cancer and Prostatic Diseases]
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Researchers showed that miR-135a was aberrantly downregulated in non-small cell lung cancer (NSCLC) cells in comparison with normal bronchial epithelial cells, and the expression of miR-135a inhibited proliferation, invasion and metastasis of NSCLC cells in vitro.
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The authors demonstrated that the Hippo kinases LATS1/2 and MST1/2, which inhibited YAP activity, were required for maintaining Wnt signaling and canonical stem cell function.
[Cell Stem Cell]
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Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
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Scientists explored the cellular heterogeneity of the human airway epithelium in 10 healthy living volunteers by single-cell RNA profiling. 77,969 cells were collected at 35 distinct locations, from the nose to the 12th division of the airway tree.
[American Journal of Respiratory and Critical Care Medicine]
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Scientists analyzed the fusion process in connection with structure and mechanical properties of the spheroids from human somatic cells of different phenotypes: mesenchymal stem cells from the limbal eye stroma and epithelial cells from retinal pigment epithelium.
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Kosheleva, N. V., Efremov, Y. M., Shavkuta, B. S., Zurina, I. M., Zhang, D., Zhang, Y., Minaev, N. V., Gorkun, A. A., Wei, S., Shpichka, A. A., Saburina, I. N., & Timashev, P. S. (2020). Cell spheroid fusion: beyond liquid drops model. Scientific Reports, 10(1), 12614. https://doi.org/10.1038/s41598-020-69540-8 Cite
Using CYP4V2 mutant PSCs as disease models, scientists demonstrated that retinal pigmented epithelial cells with CYP4V2 mutations presented a disrupted fatty acid homeostasis, which were characterized with excessive accumulation of poly-unsaturated fatty acid.
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Zhang, Z., Yan, B., Gao, F., Li, Q., Meng, X., Chen, P., Zhou, L., Deng, W., Li, C., Xu, W., Han, S., Feng, H., Li, Y., Chen, J., Yin, Z., Liao, C., Tse, H.-F., Xu, A., & Lian, Q. (2020). Pluripotent Stem Cells Reveal Poly-unsaturated Fatty Acids-provoked Mitochondrial Stress as a Central Node Potentiating Retinal Pigmented Epithelium Degeneration in Bietti’s Crystalline Dystrophy. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.07.024 Cite