epithelial cells

[Developmental Cell] Scientists showed that in a high-turnover tissue, severe damage to the differentiated compartment induced progenitors to transiently acquire a unique transcriptional and morphological postmitotic state.

[Thorax] Scientists discuss the interplay between lung endothelial cell, immune cells and Mycobacterium tuberculosis (Mtb) and argue that modeling these interactions is of key importance to unravel early events during Mtb infection.

[Stem Cell Reports] The authors found that, despite the enrichment of histone 3 lysine 79 methylation on thousands of actively transcribed genes in somatic cells, disruptor of telomeric silencing 1-like (DOT1L) inhibition did not immediately cause the shutdown of the somatic transcriptional profile to enable transition to pluripotency.

[Cellular and Molecular Life Sciences] Researchers investigated the molecular mechanisms that determined intercellular adhesion receptor (ICAM)-1 localization into apical membrane domains of polarized hepatic epithelial cells, and their effect on lymphocyte-hepatic epithelial cell interaction.

[Communications Biology] By analysing publicly available transcriptomic data of patient samples and cell lines, researchers identified here two specific glycan profiles in pancreatic ductal adenocarcinoma that correlated with progression, clinical outcome and epithelial to mesenchymal transition status.

[Scientific Reports] Researchers explored the involvement of epithelial GPR120 in the colorectal cancer development. Both in vitro and in vivo experiments were conducted to mimic the conditional deletion of the receptor from gut epithelium.