Wnt/β‐Catenin Signaling Is Critical for Regenerative Potential of Distal Lung Epithelial Progenitor Cells in Homeostasis and Emphysema

Researchers identified an organoid‐forming adult distal lung epithelial progenitor cell population characterized by a low Wnt/β‐catenin activity, which was enriched in club and alveolar epithelial type II cells.
[Stem Cells]
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Integrin α5β1, as a Receptor of Fibronectin, Binds the FbaA Protein of Group A Streptococcus to Initiate Autophagy during Infection

The authors stimulated cells and infected mice with M and FbaA mutants of M1 Group A Streptococcus strain SF370 or with purified M and FbaA proteins, and found that only FbaA protein was involved in autophagy induction.
[mBio]
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Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells

Improving methods for liver decellularization, recellularization, and differentiation of different liver cellular lineages of human iPSCs in an organ-like environment, investigators generated functional engineered human mini-livers and performed transplantation in a rat model.
[Cell Reports]
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The Msi1-mTOR Pathway Drives the Pathogenesis of Mammary and Extramammary Paget’s Disease

Investigators identified MSI1 ectopic overexpression in basal epithelial cells of human Paget’s disease (PD) skin, and showed that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological, single-cell and molecular levels.
[Cell Research]
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