epithelial cells

[Cell Death & Disease] The authors used the breast cancer mouse model MMTV-PyMT, and constructed a single-cell atlas of 31,778 cells from four distinct stages of tumor progression, during which malignant transition occured.

[Scientific Reports] Researchers demonstrated the versatile applicability of the new MMTV-Flp strain and manipulated genes in a temporally and spatially controlled manner in the normal mammary gland, in luminal-type mammary tumors that overexpressed ERBB2, and in a new KRAS-associated mammary cancer model.

[Experimental & Molecular Medicine] Scientists focus on adult gastrointestinal organoids and summarize the state-of-the-art protocols for successful transgenesis.

[Scientific Reports] Researchers investigated whether electroporation-mediated gene transfer of MRCKα to the lungs can attenuate LPS-induced acute lung injury in vivo.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated that FRS2β, an adaptor protein expressed in a small subset of epithelial cells, triggered the proinflammatory changes that induced stroma in premalignant mammary tissues and was responsible for the disease onset.

[Oncogene] Genetic deletion of all miR-200s in the human gastric cancer cell lines induced potent morphological alterations, G1/S cell cycle arrest, increased senescence-associated β-galactosidase activity, and aberrant metabolism, collectively resembling the senescent phenotype.