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epithelial cells

Aluminum Induced Intestinal Dysfunction via Mechanical, Immune, Chemical and Biological Barriers

[Chemosphere] Aluminum treatment can regulate intestinal composition and bio-enzyme activity, impairing the function of chemical barrier.

Lung Epithelial and Endothelial Damage, Loss of Tissue Repair, Inhibition of Fibrinolysis, and Cellular Senescence in Fatal COVID-19

[Science Translational Medicine] Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.

Cis-Acting Lnc-Cxcl2 Restrains Neutrophil-Mediated Lung Inflammation by Inhibiting Epithelial Cell CXCL2 Expression in Virus Infection

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified an inducible lncRNA in the Cxcl2 gene locus, lnc-Cxcl2, which could selectively inhibit Cxcl2 expression in mouse lung epithelial cells but not in macrophages.

CCCTC-Binding Factor Transcriptionally Regulates Galectin-7 and Activates the JNK/STAT3 Axis to Aggravate Bronchial Epithelial Cell Injury

[Pediatric Pulmonology] Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.

In Vitro Genotoxicity of Dibutyl Phthalate on A549 Lung Cells at Air-Liquid Interface in Exposure Concentrations Relevant at Workplaces

[Environmental and Molecular Mutagenesis] While in vitro studies were often based on submerged exposures, this study aimed to expose A549 alveolar epithelial cells at the air-liquid interface (ALI) to unravel the genotoxic and oxidative stress-inducing potential of dibutyl phthalate (DBP) with concentrations relevant at occupational settings.

Fluid Flow Exposure Promotes Epithelial-to-Mesenchymal Transition and Adhesion of Breast Cancer Cells to Endothelial Cells

[Breast Cancer Research] Researchers showed that fluid forces on the order of 1 Pa promoted epithelial-to-mesenchymal transition and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations.

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