epithelial cells

[Nature] Researchers use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and up to 11 distinct anatomical regions in the healthy paediatric and adult human gut.

[Mucosal Immunology] Scientists elucidated the contribution of central mechanisms of regulated cell death and upstream regulatory components during gastrointestinal infection.

[Cell Host & Microbe] The authors showed that the Shigella ubiquitin ligase IpaH7.8 functions as an inhibitor of the pore-forming protein gasdermin.

[PLOS Pathogens] Scientists reported the discovery of ethacridine as a potent drug against SARS-CoV-2. Ethacridine was identified via high-throughput screening of an FDA-approved drug library in living cells using a fluorescence assay.

[Cell Death & Disease] Scientists reported that a chromatin modulator protein arginine N-methyltransferase 4/coactivator-associated arginine methyltransferase 1 was elevated in human lung tissues with pneumonia and in experimental lung injury models.

[Journal of Gastroenterology and Hepatology] Researchers investigated the role of transmembrane G-protein-coupled receptor in wound healing in the context of colonic epithelial cells in the presence of bile acids.