extracellular matrix

[Translational Oncology] Investigators suggested that stiffer substrate enhanced melanoma development by upregulating SNF5 expression, and SNF5 was a key mediator of stiffer matrix-induced immune evasion of melanoma cancer cells.

[Cancer] Researchers review the role of tumor-infiltrating Tregs in tumor progression and metabolic reprogramming of the tumor microenvironment.

[Journal of Biomaterials Science-Polymer Edition] Researchers probed the use of new biomimetic sulphonated polyether ether ketone-based nanofibrous scaffold to deliver amine functionalized hydroxyapatite nanoparticles loaded resveratrol for its potent functionality in osteogenic differentiation.

[Stem Cell Reviews and Reports] Investigators proposed a 3D environment based on gallic acid grafted-chitosan scaffold and osteoblasts differentiated from human umbilical cord mesenchymal stem cells to recapitulate the main components of hematopoietic stem cells niche.

[Journal of Biological Engineering] Scientists discuss bone structure, properties of an ideal scaffold, the potential of decellularized bone as bioscaffolds, terminal sterilization of decellularized bone, cell removing confirmation in decellularized tissues, and post decellularization procedures.

[Nature Review Cardiology] The author summarizes the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discussing challenges and opportunities for therapeutic translation.