extracellular matrix

[Nature Communications] Investigators developed StemBond hydrogels, a hydrogel in which matrix tethering was robust and could be varied independently of stiffness, and validated it by showing that they provided an optimal system for culturing mouse and human pluripotent stem cells.

[Scientific Reports] Scientists tested four methods to decellularize human cardiac tissue and evaluated their efficiency in terms of cell removal and preservation of key ECM components, such as collagens and sulfated glycosaminoglycans.

[FEBS Journal] Scientists reported on the epidermal growth factor receptor (EGFR)-estrogen receptor beta (ERβ) functional relationship in connection to the aggressiveness and cancer stem cell-like characteristics of triple-negative breast cancer cells.

[Experimental and Molecular Medicine] Investigators used thrombolytic nanocages with multivalent clot-targeting peptides and fibrin degradation enzymes, such as microplasmin, to dissolve fibrin in the tumor microenvironment and named them fibrinolytic nanocages.

[Bone Marrow Transplantation] Investigators provide an overview of the cellular therapies available for the management of systemic sclerosis, including systemically injected therapies and locally administered regenerative cell therapies.

[International Journal of Urology] The authors summarize the development and applications of three-dimensional organoid cultures in urological cancers, mainly focusing on prostate, urinary bladder and kidney cancers, and assess the future prospects of this model.