extracellular matrix

[Science Advances] ECM proteins, collagen I, collagen III, and elastin, blocked natural killer (NK) cell cytotoxicity and promoted their chemokine/cytokine production. NK cell cytotoxicity against major histocompatibility complex class I (MHC-I)–deficient melanoma in the skin was markedly increased by blocking tumor collagen deposition.

[Science Advances] Researchers fabricated poly(ε-caprolactone) fiber skeletons (PSs) that were subcutaneously embedded to induce the assembly of host cells and ECM to obtain PS-reinforced biotubes.

[Advanced Healthcare Materials] The authors presented a method for inducing controlled tumor angiogenesis by engineering the microenvironment that could aid in the development of effective anticancer drugs and cancer immunotherapy.

[EMBO Reports] Scientists used cerebral organoids derived from patients and genome edited-iPSCs to address pathophysiological changes associated with a complex malformation of human cortical development caused by mutations in the echinoderm microtubule-associated protein-like 1 (EML1) gene.

[Nature Communications] The authors identified the class of cellular inhibitor of apoptosis protein-1/2 inhibitors as inducing cell death selectively in SOX10-deficient cells.

[Experimental & Molecular Medicine] Scientists showed that bone marrow-derived MSCs contributed to fibrosis in myeloproliferative neoplasms by differentiating into αSMA-positive myofibroblasts.