fibroblasts

[Biomedicine & Pharmacotherapy] Sphaerococcenol A capacity to impact colorectal-CSCs tumorspheres was evaluated by determining tumorspheres viability, number, and area, as well as the proteasome inhibitory activity.

[Stem Cell Reports] Scientists report successful targeting of the CCR5 locus in iPSCs generated from T cells or fibroblasts from Mauritian cynomolgus macaques, using CRISPR-Cas9 technology.

[JCI Insight] Researchers determined the anti-fibrotic efficacy and potential mechanisms of bromodomain and extra-terminal domain proteins inhibition in systemic sclerosis.

[Photochemistry and Photobiology] Researchers compared the anti-photoaging effects of injectable platelet-rich fibrin in UVA-irradiated human dermal fibroblasts with those of platelet-rich plasma by examining cell proliferation, migration, and apoptosis, ROS generation, matrix metalloproteinase and collagen I levels.

[Nature Communications] Scientists profiled 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidated the potential origin and regulation of tumor-enriched cell types in colorectal cancer.

[Molecular Cancer Research] Scientists found that cancer-associated fibroblasts predominantly secreted hepatocyte growth factor (HGF) and activated MET receptor tyrosine kinase in TNBC cells.