Compared to normal mammary gland tissues, cross-linked hyaluronan levels were significantly decreased in breast cancer and associated with tumor malignancy.
[Cell Death & Disease]
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To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, researchers analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.
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Reserachers studied transcriptome profiles of human nail units using polydactyly specimens. Single-cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6, respectively.
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Kim, H. J., Shim, J. H., Park, J.-H., Shin, H. T., Shim, J. S., Jang, K.-T., Park, W.-Y., Lee, K.-H., Kwon, E. J., Jang, H.-S., Yang, H., Lee, J. H., Yang, J.-M., & Lee, D. (2021). Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-02223-w Cite
Marine macroalgae species Ulva sp. and Cladophora sp. were selected for their structural variations, porous and fibrous respectively, and evaluated as alternative ECM candidates.
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The endothelin-1 in the functional hydrogels significantly promoted the proliferation, migration and angiogenesis-related gene expression of human umbilical vein endothelial cells and fibroblasts.
[Journal of Materials Chemistry B]
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Investigators constructed PRL-1 overexpressed human placental mesenchymal stem cells in an attempt to enhance the suppressive function of adipogenesis in Graves’ ophthalmopathy animal models.
[Stem Cell Research & Therapy]
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Park, M., Kim, J. Y., Kang, J. M., Lee, H. J., Banga, J. P., Kim, G. J., & Lew, H. (2021). PRL-1 overexpressed placenta-derived mesenchymal stem cells suppress adipogenesis in Graves’ ophthalmopathy through SREBP2/HMGCR pathway. Stem Cell Research & Therapy, 12(1), 304. https://doi.org/10.1186/s13287-021-02337-2 Cite
Scientists evaluated OxiumTMEXO, a regulatory complying medium, with respect to production capacity and conservation of the extracellular vesicle’s characteristics and functionality and the parental cell’s phenotype and viability.
[Frontiers in Bioengineering and Biotechnology]
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Researchers created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and conducted RNA-seq to identify differentially expressed genes (DEGs) and the biological processes and pathways altered in MAND.
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Mullegama, S. V., Klein, S. D., Williams, S. R., Innis, J. W., Probst, F. J., Haldeman-Englert, C., Martinez-Agosto, J. A., Yang, Y., Tian, Y., Elsea, S. H., & Ezashi, T. (2021). Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes. Scientific Reports, 11(1), 11295. https://doi.org/10.1038/s41598-021-90798-z Cite
Scientists identified cell–cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.
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Prompted by findings in patient biopsies, scientists used the model to investigate the role of platelets in malignant cell invasion and ECM production.
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Researchers evaluated the commercially-available decellularized skin dermis ECM Alloderm for efficacy in providing structure to biological engineered blood vessels.
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Patel, B., Wonski, B. T., Saliganan, D. M., Rteil, A., Kabbani, L. S., & Lam, M. T. (2021). Decellularized dermis extracellular matrix alloderm mechanically strengthens biological engineered tunica adventitia-based blood vessels. Scientific Reports, 11(1), 11384. https://doi.org/10.1038/s41598-021-91005-9 Cite