Reduced Hyaluronan Cross-Linking Induces Breast Cancer Malignancy in a Caf-Dependent Manner

Compared to normal mammary gland tissues, cross-linked hyaluronan levels were significantly decreased in breast cancer and associated with tumor malignancy.
[Cell Death & Disease]
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Osteogenic Differentiation of Human Mesenchymal Stromal Cells and Fibroblasts Differs Depending on Tissue Origin and Replicative Senescence

To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, researchers analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.
[Scientific Reports]
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Single-Cell RNA Sequencing of Human Nail Unit Defines RSPO4 Onychofibroblasts and SPINK6 Nail Epithelium

Reserachers studied transcriptome profiles of human nail units using polydactyly specimens. Single-cell RNAseq with 11,541 cells from 4 extra digits revealed nail-specific mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6, respectively.
[Communications Biology]
Kim, H. J., Shim, J. H., Park, J.-H., Shin, H. T., Shim, J. S., Jang, K.-T., Park, W.-Y., Lee, K.-H., Kwon, E. J., Jang, H.-S., Yang, H., Lee, J. H., Yang, J.-M., & Lee, D. (2021). Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-02223-w Cite
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Seaweed Cellulose Scaffolds Derived from Green Macroalgae for Tissue Engineering

Marine macroalgae species Ulva sp. and Cladophora sp. were selected for their structural variations, porous and fibrous respectively, and evaluated as alternative ECM candidates.
[Scientific Reports]
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Gelatin Methacryloyl Hydrogels Functionalized with Endothelin-1 for Angiogenesis and Full-Thickness Wound Healing

The endothelin-1 in the functional hydrogels significantly promoted the proliferation, migration and angiogenesis-related gene expression of human umbilical vein endothelial cells and fibroblasts.
[Journal of Materials Chemistry B]
Li, M.-N., Yu, H.-P., Ke, Q.-F., Zhang, C.-Q., Gao, Y.-S., & Guo, Y.-P. (2021). Gelatin methacryloyl hydrogels functionalized with endothelin-1 for angiogenesis and full-thickness wound healing. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00449B Cite
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PRL-1 Overexpressed Placenta-Derived Mesenchymal Stem Cells Suppress Adipogenesis in Graves’ Ophthalmopathy through SREBP2/HMGCR Pathway

Investigators constructed PRL-1 overexpressed human placental mesenchymal stem cells in an attempt to enhance the suppressive function of adipogenesis in Graves’ ophthalmopathy animal models.
[Stem Cell Research & Therapy]
Park, M., Kim, J. Y., Kang, J. M., Lee, H. J., Banga, J. P., Kim, G. J., & Lew, H. (2021). PRL-1 overexpressed placenta-derived mesenchymal stem cells suppress adipogenesis in Graves’ ophthalmopathy through SREBP2/HMGCR pathway. Stem Cell Research & Therapy, 12(1), 304. https://doi.org/10.1186/s13287-021-02337-2 Cite
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A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles from Mesenchymal Stem Cells

Scientists evaluated OxiumTMEXO, a regulatory complying medium, with respect to production capacity and conservation of the extracellular vesicle’s characteristics and functionality and the parental cell’s phenotype and viability.
[Frontiers in Bioengineering and Biotechnology]
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Transcriptome Analysis of MBD5-Associated Neurodevelopmental Disorder (MAND) Neural Progenitor Cells Reveals Dysregulation of Autism-Associated Genes

Researchers created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and conducted RNA-seq to identify differentially expressed genes (DEGs) and the biological processes and pathways altered in MAND.
[Scientific Reports]
Mullegama, S. V., Klein, S. D., Williams, S. R., Innis, J. W., Probst, F. J., Haldeman-Englert, C., Martinez-Agosto, J. A., Yang, Y., Tian, Y., Elsea, S. H., & Ezashi, T. (2021). Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes. Scientific Reports, 11(1), 11295. https://doi.org/10.1038/s41598-021-90798-z Cite
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Engineering Aligned Human Cardiac Muscle Using Developmentally Inspired Fibronectin Micropatterns

Scientists identified cell–cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.
[Scientific Reports]
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A Human Multi-Cellular Model Shows How Platelets Drive Production of Diseased Extracellular Matrix and Tissue Invasion

Prompted by findings in patient biopsies, scientists used the model to investigate the role of platelets in malignant cell invasion and ECM production.
[iScience]
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Decellularized Dermis Extracellular Matrix Alloderm Mechanically Strengthens Biological Engineered Tunica Adventitia-Based Blood Vessels

Researchers evaluated the commercially-available decellularized skin dermis ECM Alloderm for efficacy in providing structure to biological engineered blood vessels.
[Scientific Reports]
Patel, B., Wonski, B. T., Saliganan, D. M., Rteil, A., Kabbani, L. S., & Lam, M. T. (2021). Decellularized dermis extracellular matrix alloderm mechanically strengthens biological engineered tunica adventitia-based blood vessels. Scientific Reports, 11(1), 11384. https://doi.org/10.1038/s41598-021-91005-9 Cite
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