fibroblasts

[Communications Biology] Researchers explored the metabolic reprogramming relevant to lung adenocarcinoma metastasis and decoded the underlying intercellular alterations.

[Nature Cardiovascular Research] The authors identified cell-specific transcriptional signatures associated with age and heart failure and reveal the emergence of disease-associated cell states. Notably, cardiomyocytes converged toward common disease-associated cell states, whereas fibroblasts and myeloid cells underwent dramatic diversification.

[Biotechnology and Bioengineering] Scientists investigated whether Schwann cells could be involved in the disease pathogenesis, and developed a tissue-engineered 3D in vitro model that combined motor neurons cocultured with astrocytes.

[IUBMB Life] The authors highlight the vital functions of hyaluronan (HA) in cancer cell initiation and progression as well as HA-mediated paracrine interactions among cancer and stromal cells.

[Cancer Research] The authors focus on the role of leucine-rich repeat-containing protein (LRRC15) in cancer, including clinical trials involving LRRC15-targeted therapies, such as the ABBV-085 ADC for patients with LRRC15-positive tumors.

[Basic Research in Cardiology] Researchers established an in vitro iPSC model of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and examined whether doxorubicin-treated ACT-iPSC cardiomyocytes could recapitulate the clinical features exhibited by patients.