fibronectin

[Scientific Reports] To establish appropriate ex vivo models for a glaucomatous trabecular meshwork, 2D and 3D cultures of HTM were prepared in the presence of 250 nM dexamethasone or 5 ng/mL TGFβ2, and characterized by various analyses.

[eLife] The authors used a highly specific integrin α5β1 peptidomimetic combined with nanopatterned hydrogels to show that keratinocyte sheets regulated their migration ability at an optimal integrin α5β1 nanospacing.

[Journal of the American Heart Association] Investigators examined mice in which integrin α5 was replaced with the α5/2 chimera, using the transverse aortic constriction and partial carotid ligation models of vessel remodeling.

[Scientific Reports] Using micro-fabricated channels, researchers demonstrated that metastatic, A375-M2, melanoma cells adopt features of both mesenchymal and bleb-based migration.

[ACS Nano] Investigators developed a size switchable nanosystem based on PEG–PLGA nanospheres encapsulated within liposomes for the combined delivery of vactosertib, a TGF-β1 receptor kinase inhibitor, and the cytotoxic drug paclitaxel.

[Cell Reports] Scientists showed that deletion of the scaffold protein Angiomotin (Amot) inhibited migration and expansion of the physiological and pathological vascular network