glioblastoma stem cells

[Nature Communications] Investigators identified E3 ligase competition as a critical mechanism of SOX2 regulation, with functional consequences for glioblastoma stem cells identity and maintenance.

[Journal of Histochemistry & Cytochemistry] Scientists review recent literature on energy production in glioblastoma stem cells and leukemic stem cells versus their normal counterparts, neural stem cells and hematopoietic stem cells, respectively.

[Journal of Experimental Medicine] The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.

[International Journal of Oncology] As the tumor microenvironment is typically acidic due to increased glycolysis and consequently leads to an increased production of lactic acid in tumor cells, the role of acid‑sensing ion channel 1a (ASIC1a), an acid sensor, was explored as a tumor suppressor in gliomagenesis and stemness.

[Cell Reports] The authors dissected the genetic and functional heterogeneity of human glioblastoma stem cells within patients by their innate responses to non-pathogenic mouse parvoviruses that were tightly restrained by cellular physiology.

[Nature Cancer] Investigators identified chemical inhibitors for PUS7 and showed that these compounds prevented pseudouridine synthase 7 (PUS7)-mediated pseudouridine modification, suppressed tumorigenesis and extended the life span of tumor-bearing mice.