Targeting PUS7 Suppresses tRNA Pseudouridylation and Glioblastoma Tumorigenesis

By
Justin.choi
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Investigators identified chemical inhibitors for PUS7 and showed that these compounds prevented pseudouridine synthase 7 (PUS7)-mediated pseudouridine modification, suppressed tumorigenesis and extended the life span of tumor-bearing mice.
[Nature Cancer]
Cui, Q., Yin, K., Zhang, X., Ye, P., Chen, X., Chao, J., Meng, H., Wei, J., Roeth, D., Li, L., Qin, Y., Sun, G., Zhang, M., Klein, J., Huynhle, M., Wang, C., Zhang, L., Badie, B., Kalkum, M., … Shi, Y. (2021). Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis. Nature Cancer, 1–18. https://doi.org/10.1038/s43018-021-00238-0 Cite
Abstract