glioblastoma

[Cell Reports] Investigators showed that patient-derived glioma-stem cells recruited elevated levels of proteins that ensure the temporal cilium disassembly, leading to suppressed ciliogenesis.

[Analytical Chemistry] The authors demonstrated the capability of using an ultrahigh-frequency range dielectrophoresis fluidic biosensor as a detector. This implied an important methodological adaptation of sedimentation field-flow fractionation cell sorting by the use of a new compatible carrier liquid DEP buffer.

[Journal of Experimental & Clinical Cancer Research] Patient-derived glioma stem-like cells, glioblastoma (GBM) cell lines, intracranial GBM xenografts, and GBM sections were used to measure mRNA and protein expression and determine the related molecular mechanisms by qRT-PCR, immunoblot, immunoprecipitation, immunofluorescence, OCR, ECAR, live-cell imaging, and immunohistochemistry.

[Cell Reports] Scientists showed that patient-derived glioma stem cells recruited elevated levels of proteins that ensured the temporal cilium disassembly, leading to suppressed ciliogenesis.

[Journal of Medicinal Chemistry] Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Scientists reported the design, synthesis, molecular modeling, and biological evaluation of novel HO-1 inhibitors.

[Cell Reports] The authors reported that the LGALS1 gene, encoding the carbohydrate binding protein, galectin1, is a key regulator of brain tumor stem cells and glioblastoma resistance to therapy.