glioblastoma

[IN8bio, Inc.] IN8bio, Inc. announced completion of dosing of the first patient cohort in a Phase I clinical trial of INB-100, a donor-derived gamma-delta T cell therapeutic in development for patients with leukemia undergoing haploidentical stem cell transplant.

[Biomed Research International] Three datasets were used to perform the analysis to search for the key genes related to glioma stem cell, temozolomide resistance, and prognosis. The key gene for further research was selected by reviewing the previous studies.

[Translational Oncology] Scientists identified a novel mechanism of biphasic activation of STAT3 in response to gp130-linked cytokines, including interleukin-6 (IL6), in which activation of STAT3 is prolonged by circumventing the negative regulatory mechanisms induced by its initial activation

[Scientific Reports] Scientists showed that interaction with tumor microenvironment elements, mainly activated monocytes through IL-6 secretion, and the extracellular matrix protein fibronectin, induced the Stat3 transcriptional pathway and upregulated ODZ1 which resulted in glioblastoma cell migration.

[Acta Pharmacologica Sinica] Researchers carried out research to discover a novel alternative drug targeting the oncogenic NFAT signaling pathway for Glioblastoma multiforme therapy.

[Scientific Reports] Scientists revealed significant alterations in miRNA expression across three glioblastoma tumor regions: the core, rim, and invasive margin.