Glioblastoma Invasion Factor ODZ1 Is Induced by Microenvironmental Signals through Activation of a Stat3-Dependent Transcriptional Pathway

Scientists showed that interaction with tumor microenvironment elements, mainly activated monocytes through IL-6 secretion, and the extracellular matrix protein fibronectin, induced the Stat3 transcriptional pathway and upregulated ODZ1 which resulted in glioblastoma cell migration.