Tag Archives: monocytes

Anti-CLL1 Chimeric Antigen Receptor T Cell Therapy in Children with Relapsed/Refractory Acute Myeloid Leukemia

Scientists tested the safety and efficacy of chimeric antigen receptor T cell therapy in refractory/relapsed acute myeloid leukemia .
[Clinical Cancer Research]
Zhang, H., Wang, P., Li, Z., He, Y., Gan, W., & Jiang, H. (2021). Anti-CLL1 chimeric antigen receptor T cell therapy in children with relapsed/refractory acute myeloid leukemia. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4543 Cite
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Efficient Conversion of Human Induced Pluripotent Stem Cells Into Microglia by Defined Transcription Factors

The authors report a novel approach that produces, within ten days, the differentiation of human induced pluripotent stem cells into microglia by forced expression of both SPI1 and CEBPA.
[Stem Cell Reports]
Chen, S.-W., Hung, Y.-S., Fuh, J.-L., Chen, N.-J., Chu, Y.-S., Chen, S.-C., Fann, M.-J., & Wong, Y.-H. (2021). Efficient conversion of human induced pluripotent stem cells into microglia by defined transcription factors. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.03.010 Cite
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MCPIP1-Mediated NFIC Alternative Splicing Inhibits Proliferation of Triple-Negative Breast Cancer via Cyclin D1-RB-E2F1 Axis

Investigators showed that monocyte chemotactic protein induced protein 1 (MCPIP1) was downregulated in 80 TNBC tissues and five TNBC cell lines compared to adjacent paracancerous tissues and one human immortalized breast epithelial cell line, while its high expression levels were associated with increased overall survival in TNBC patients.
[Cell Death & Disease]
Chen, F., Wang, Q., Yu, X., Yang, N., Wang, Y., Zeng, Y., Zheng, Z., Zhou, F., & Zhou, Y. (2021). MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis. Cell Death & Disease, 12(4), 1–16. https://doi.org/10.1038/s41419-021-03661-4 Cite
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The Mechanistic Basis of Protection by Non-neutralizing Anti-Alphavirus Antibodies

Scientists evaluated the activity of 13 non-neutralizing monoclonal antibodies against Mayaro virus, an emerging arthritogenic alphavirus.
[Cell Reports]
Earnest, J. T., Holmes, A. C., Basore, K., Mack, M., Fremont, D. H., & Diamond, M. S. (2021). The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108962 Cite
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Endothelial Dysfunction and Immunothrombosis as Key Pathogenic Mechanisms in COVID-19

Scientists propose that SARS-CoV-2 infection induces a process known as immunothrombosis, in which activated neutrophils and monocytes interact with platelets and the coagulation cascade, leading to intravascular clot formation in small and larger vessels.
[Nature Reviews Immunology]
Bonaventura, A., Vecchié, A., Dagna, L., Martinod, K., Dixon, D. L., Van Tassell, B. W., Dentali, F., Montecucco, F., Massberg, S., Levi, M., & Abbate, A. (2021). Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nature Reviews Immunology, 1–11. https://doi.org/10.1038/s41577-021-00536-9 Cite
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The Anti-inflammatory Cytokine Interleukin-37 Is an Inhibitor of Trained Immunity

The authors showed that administration of recombinant IL-37 abrogated the protective effects of TI in vivo, as revealed by reduced host pro-inflammatory responses and survival to disseminated candidiasis.
[Cell Reports]
Cavalli, G., Tengesdal, I. W., Gresnigt, M., Nemkov, T., Arts, R. J. W., Domínguez-Andrés, J., Molteni, R., Stefanoni, D., Cantoni, E., Cassina, L., Giugliano, S., Schraa, K., Mills, T. S., Pietras, E. M., Eisenmensser, E. Z., Dagna, L., Boletta, A., D’Alessandro, A., Joosten, L. A. B., … Dinarello, C. A. (2021). The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108955 Cite
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Phenotypic Characterization of Leukemia-Initiating Stem Cells in Chronic Myelomonocytic Leukemia

Scientists found that leukemic stem cells in chronic myelomonocytic leukemia resided in a CD34+/CD38− fraction of the malignant clone.
[Leukemia]
Eisenwort, G., Sadovnik, I., Keller, A., Ivanov, D., Peter, B., Berger, D., Stefanzl, G., Bauer, K., Slavnitsch, K., Greiner, G., Gleixner, K. V., Sperr, W. R., Willmann, M., Sill, H., Bettelheim, P., Geissler, K., Deininger, M., Rülicke, T., & Valent, P. (2021). Phenotypic characterization of leukemia-initiating stem cells in chronic myelomonocytic leukemia. Leukemia, 1–12. https://doi.org/10.1038/s41375-021-01227-z Cite
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Monocyte Progenitors Give Rise to Multinucleated Giant Cells

Researchers showed that the giant cell-forming potential is a particular trait of monocyte progenitors.
[Nature Communications]
Lösslein, A. K., Lohrmann, F., Scheuermann, L., Gharun, K., Neuber, J., Kolter, J., Forde, A. J., Kleimeyer, C., Poh, Y. Y., Mack, M., Triantafyllopoulou, A., Dunlap, M. D., Khader, S. A., Seidl, M., Hölscher, A., Hölscher, C., Guan, X. L., Dorhoi, A., & Henneke, P. (2021). Monocyte progenitors give rise to multinucleated giant cells. Nature Communications, 12(1), 2027. https://doi.org/10.1038/s41467-021-22103-5 Cite
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Macrophages in Microgravity: The Impact of Space on Immune Cells

Scientists review and summarize the literature investigating the effects of microgravity on macrophages and monocytes regarding the microgravity environment simulation/generation methods, cell sources, experiment durations, and parameters of interest utilized within the field.
[npj Microgravity]
Ludtka, C., Silberman, J., Moore, E., & Allen, J. B. (2021). Macrophages in microgravity: the impact of space on immune cells. Npj Microgravity, 7(1), 1–10. https://doi.org/10.1038/s41526-021-00141-z Cite
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Ontogenic Shifts in Cellular Fate Are Linked to Proteotype Changes in Lineage-Biased Hematopoietic Progenitor Cells

Through deep coverage of the cellular proteome of fetal and adult lympho-myeloid multipotent progenitors, common lymphoid progenitors, and granulocyte-monocyte progenitors, researchers established that features traditionally attributed to adult hematopoiesis were conserved across lymphoid and myeloid lineages.
[Cell Reports]
Jassinskaja, M., Pimková, K., Arh, N., Johansson, E., Davoudi, M., Pereira, C.-F., Sitnicka, E., & Hansson, J. (2021). Ontogenic shifts in cellular fate are linked to proteotype changes in lineage-biased hematopoietic progenitor cells. Cell Reports, 34(12). https://doi.org/10.1016/j.celrep.2021.108894 Cite
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Single-Cell Profiling of Myeloid Cells in Glioblastoma across Species and Disease Stage Reveals Macrophage Competition and Specialization

Scientists employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune landscape in mouse tumors and in patients with newly diagnosed disease or recurrence.
[Nature Neuroscience]
Pombo Antunes, A. R., Scheyltjens, I., Lodi, F., Messiaen, J., Antoranz, A., Duerinck, J., Kancheva, D., Martens, L., De Vlaminck, K., Van Hove, H., Kjølner Hansen, S. S., Bosisio, F. M., Van der Borght, K., De Vleeschouwer, S., Sciot, R., Bouwens, L., Verfaillie, M., Vandamme, N., Vandenbroucke, R. E., … Movahedi, K. (2021). Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature Neuroscience, 1–16. https://doi.org/10.1038/s41593-020-00789-y Cite
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