Mesenchymal Stromal Cell-Derived Septoclasts Resorb Cartilage during Developmental Ossification and Fracture Healing

Scientists showed that matrix degradation and chondrocyte phagocytosis were mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which had a mesenchymal origin and were not derived from hematopoietic cells.
[Nature Communications]
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Matrix Metalloproteinases (MMP) 3 and 9 as Biomarkers of Severity in COVID-19 Patients

Investigators studied serum MMP3 and MMP9 as potential biomarkers of COVID-19 severity, in 108 hospitalized patients with different World Health Organization severity stage and in 48 controls.
[Scientific Reports]
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NLRP3 Inflammasome Activation in Human Peripheral Blood Mononuclear Cells Induced by Venoms Secreted PLAM2s

Peripheral blood mononuclear cells were isolated by density gradient and incubated with RPMI, LPS, BthTX-I or BthTX-II isolated from Bothrops jararacussu venom, to evaluate viability, and the results showed that there was no cell death.
[International Journal of Biological Macromolecules]
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M-CSF Supports Medullary Erythropoiesis and Erythroid Iron Demand Following Burn Injury through Its Activity on Homeostatic Iron Recycling

The authors found M-CSF secretion was increased in burn patients and a murine model of post burn ACI, so they neutralized M-CSF in ACI mice to determine if erythropoiesis was improved.
[Scientific Reports]
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Single-Cell Multi-Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

Investigators used multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab.
[Nature Communications]
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Endothelial Thrombomodulin Downregulation Caused by Hypoxia Contributes to Severe Infiltration and Coagulopathy in COVID-19 Patient Lungs

Pulmonary endothelial cells become dysfunctional during COVID-19, showing a loss of thrombomodulin expression related to severe thrombosis and infiltration, and endothelial cell dysfunction might be caused by a pathologic condition in COVID-19 patient lungs rather than a direct infection with SARS-CoV-2.
[Ebiomedicine]
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CCR2 Promotes Monocyte Recruitment and Intestinal Inflammation in Mice Lacking the Interleukin-10 Receptor

Investigators asked whether CCR2 was necessary for the development of colitis in mice lacking the receptor for IL10.
[Scientific Reports]
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Boosting NAD+ Blunts Toll-Like Receptor-4 Induced Type-I Interferon in Control and Systemic Lupus Erythematosus Monocytes

Scientists explored the underlying biology in myeloid cells from healthy volunteers following in vivo placebo or nicotinamide riboside administration and subsequently tested the findings in vitro in monocytes extracted from subjects with systemic lupus erythematosus.
[Journal of Clinical Investigation]
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Cytoplasmic Zinc Promotes IL-1β Production by Monocytes and Macrophages through mTORC1-Induced Glycolysis in Rheumatoid Arthritis

Investigators demonstrated that cytoplasmic, bioavailable zinc was essential for promoting IL-1β production in activated human monocytes and macrophages downstream of glycolysis induced by the kinase-containing multiprotein complex mTORC1.
[Science Signaling]
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Functional Characterization of the Biogenic Amine Transporters on Human Macrophages

The authors investigated the function of norepinephrine and dopamine transporters on human monocyte-derived macrophages.
[JCI Insight]
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Hyperinflammatory Environment Drives Dysfunctional Myeloid Cell Effector Response to Bacterial Challenge in COVID-19

Investigators assessed the influence of COVID-19 plasma hypercytokinemia on the functional responses of myeloid immune cells upon bacterial challenges from acute-phase COVID-19 patients and their corresponding recovery (rec)-phase.
[PLoS Pathogens]
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