Tag Archives: monocytes

Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Production of Suppressive Myeloid Cells from Human Hematopoietic Progenitor Cells In Vitro

To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.
[Science Translational Medicine]
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Inflammation, Infection and Venous Thromboembolism

Scientists discuss the contributions of inflammation and infection to venous thromboembolism.
[Circulation Research]
Colling, M. E., Tourdot, B. E., & Kanthi, Y. (2021). Inflammation, Infection and Venous Thromboembolism. Circulation Research, 128(12), 2017–2036. https://doi.org/10.1161/CIRCRESAHA.121.318225 Cite
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Monocyte Metabolic Transcriptional Programs Associate with Resistance to Tuberculin Skin Test/Interferon-γ Release Assay Conversion

To identify mechanisms of resistance to Mycobacterium tuberculosis (Mtb) infection, scientists compared transcriptional profiles from highly-exposed contacts who resist tuberculin skin test/interferon-γ release assay conversion and controls with latent Mtb infection using RNAseq.
[Journal of Clinical Investigation]
Simmons, J. D., Van, P. T., Stein, C. M., Chihota, V., Ntshiqa, T., Maenetje, P., Peterson, G. J., Reynolds, A., Benchek, P., Velen, K., Fielding, K. L., Grant, A. D., Graustein, A. D., Nguyen, F. K., Seshadri, C., Gottardo, R., Mayanja-Kizza, H., Wallis, R. S., Churchyard, G., … Hawn, T. R. (2021). Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140073 Cite
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VISTA Is an Activating Receptor in Human Monocytes

The authors discovered two novel V-domain Ig suppressor of T cell activation (VISTA) antibodies and characterized their effects on human peripheral blood mononuclear cells by scRNA/CITE-seq.
[Journal of Experimental Medicine]
Rogers, B. M., Smith, L., Dezso, Z., Shi, X., DiGiammarino, E., Nguyen, D., Sethuraman, S., Zheng, P., Choi, D., Zhang, D., Nguyen, A., McGuire, K., Liu, W., Chung, N., Chao, D. T., Ye, S., & Starbeck-Miller, G. R. (2021). VISTA is an activating receptor in human monocytes. Journal of Experimental Medicine, 218(8). https://doi.org/10.1084/jem.20201601 Cite
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Insulin Resistance Is Linked to a Specific Profile of Immune Activation in Human Subjects

Researchers tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers.
[Scientific Reports]
Cezar, R., Desigaud, D., Pastore, M., Kundura, L., Dupuy, A.-M., Cognot, C., Vincent, T., Reynes, C., Sabatier, R., Maggia, E., & Corbeau, P. (2021). Insulin resistance is linked to a specific profile of immune activation in human subjects. Scientific Reports, 11(1), 12314. https://doi.org/10.1038/s41598-021-91758-3 Cite
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Apoptotic Mesenchymal Stromal Cells Support Osteoclastogenesis While Inhibiting Multinucleated Giant Cells Formation In Vitro

Scientists focused on the communication from MSCs towards osteoclasts-like cells in vitro. MSCs seeded on a calcium-phosphate biomaterial or undergoing induced apoptosis produced a conditioned media favoring the development of osteoclasts from human CD14+ monocytes.
[Scientific Reports]
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Integrating Longitudinal Clinical Laboratory Tests with Targeted Proteomic and Transcriptomic Analyses Reveal the Landscape of Host Responses in COVID-19

Comparison of the transcriptomes of the bronchoalveolar microenvironment and peripheral blood indicates alveolar macrophages, alveolar epithelial cells, and monocytes in lungs as the potential main sources of elevated cytokines mediating systemic immune responses and organ damages.
[Cell Discovery]
Tan, Y., Zhang, W., Zhu, Z., Qiao, N., Ling, Y., Guo, M., Yin, T., Fang, H., Xu, X., Lu, G., Zhang, P., Yang, S., Fu, Z., Liang, D., Xie, Y., Zhang, R., Jiang, L., Yu, S., Lu, J., … Chen, S. (2021). Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19. Cell Discovery, 7(1), 1–19. https://doi.org/10.1038/s41421-021-00274-1 Cite
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Oncogene-Induced Maladaptive Activation of Trained Immunity in the Pathogenesis and Treatment of Erdheim-Chester Disease

Researchers reveal oncogene-induced, maladaptive induction of trained immunity in the pathogenesis of a human inflammatory myeloid neoplasm, Erdheim-Chester disease, characterized by the BRAFV600E oncogenic mutation in monocyte/macrophages and excess cytokine production.
[Blood]
Biavasco, R., Molteni, R., Stefanoni, D., Nemkov, T., Netea, M. G., Domínguez-Andrés, J., Arts, R. J., Merelli, I., Mazza, D., Zambrano, S., Panigada, M., Cantoni, E., Tengesdal, I., Maksud, P., Piras, F., De Luca, G., Cassina, L., Distefano, G., Loffreda, A., … Cavalli, G. (2021). Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood, blood.2020009594. https://doi.org/10.1182/blood.2020009594 Cite
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Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-kB-Mediated Production of CXCL1

Investigators reported that ApoE was elevated in peripheral blood monocytes in pancreatic ductal adenocarcinoma patients, and plasma ApoE protein levels stratified patient survival.
[Cancer Research]
Kemp, S. B., Carpenter, E. S., Steele, N. G., Donahue, K. L., Nwosu, Z. C., Pacheco, A., Velez-Delgado, A., Menjivar, R. E., Lima, F., The, S., Espinoza, C. E., Brown, K., Long, D., Lyssiotis, C. A., Rao, A., Zhang, Y., Magliano, M. P. di, & Crawford, H. C. (2021). Apolipoprotein E promotes immune suppression in pancreatic cancer through NF-kB-mediated production of CXCL1. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3929 Cite
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Withaferin A Inhibits Lymphocyte Proliferation, Dendritic Cell Maturation In Vitro and Prolongs Islet Allograft Survival

The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.
[Scientific Reports]
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Expression of the Myeloid Inhibitory Receptor CLEC12A Correlates with Disease Activity and Cytokines in Early Rheumatoid Arthritis

The authors postulated that CLEC12A expression on circulating myeloid cells of rheumatoid arthritis patients is associated with disease manifestations. Cell-surface, CLEC12A receptor expression was determined on circulating neutrophils and monocytes of eRA patients and of healthy donors.
[Scientific Reports]
Vaillancourt, M., Desaulniers, P., Paré, G., Pagé, N., Lachhab, A., Kerever, A., Julien, A.-S., Amiable, N., Pelletier, M., Tessier, P. A., Bessette, L., Michou, L., Fortin, P. R., & Fernandes, M. J. (2021). Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis. Scientific Reports, 11(1), 11248. https://doi.org/10.1038/s41598-021-90631-7 Cite
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