glioblastoma

[EMBO Journal] USP33 was preferentially induced in glioma stem cells by hypoxia and interacts with HIF-2alpha, leading to its stabilization through deubiquitination.

[Journal of Experimental & Clinical Cancer Research] The authors demonstrated that enhanced secretory autophagy in glioblastoma (GB) facilitated M1-like polarization of tumor associated macrophages to enhance temozolomide sensitivity of GB cells.

[International Journal of Radiation Oncology Biology Physics] Researchers presented novel mechanistic evidence relating to signaling pathways with DNA damage responses in epidermal growth factor receptor-mutated glioblastoma multiforme.

[EMBO Journal] Researchers identified USP33 as essential deubiquitinase that stabilized HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells.

[Molecular Therapy-Oncolytics] To improve CAR-T therapy for glioblastoma, a new TanCAR, comprising the tandem arrangement of IL13 and EphA2 scFv, was generated and validated in vitro and in vivo.

[Nature Communications] Researchers showed that a subset of Interleukin-10-releasing HMOX1+ myeloid cells, spatially localizing to mesenchymal-like tumor regions, drove T cell exhaustion and thus contributed to the immunosuppressive tumor microenvironment.