glioma stem cells

[Cancer Immunology Research] Scientists showed that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 in glioma stem cells drive immunosuppression in glioblastoma.

[Journal of Cancer] Investigators showed that miR-145-5p, a recently discovered miRNA, was expressed at low levels in primary glioma stem cells.

[Cell Death & Differentiation] Depletion of glycosyltransferase 8 domain containing 1 (GLT8D1) inhibited self-renewal of glioma stem cells in vitro and repressed tumor growth in glioma mouse models.

[Pathology Research and Practice] Investigators draw an interaction map for glioblastomas (GBMs) and promote awareness of the complexity of the GBM microenvironment.

[Cancer Letters] Scientists identified the gene amplification and protein overexpression of HOXA5 in glioma stem cells (GSCs) and its function in regulating GSC maintenance and the downstream transcriptional effector, to explore the significance of HOXA5 amplification/overexpression for GSC identification and prognostic determination.

[EMBO Journal] Researchers identified USP33 as essential deubiquitinase that stabilized HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells.