SMURF2 Phosphorylation at Thr249 Modifies Glioma Stemness and Tumorigenicity by Regulating TGF-β Receptor Stability

Researchers demonstrated that SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)Thr249 phosphorylation played an essential role in maintaining glioma stem cell (GSC) stemness and tumorigenicity. SMURF2 silencing augmented the self-renewal potential and tumorigenicity of patient-derived GSCs.
[Communications Biology]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Induction of Cancer Cell Stemness in Glioma through Glycolysis and the Long Noncoding RNA HULC-Activated FOXM1/AGR2/HIF-1α Axis

Brain tissues were clinically collected from 50 patients with glioblastoma and 35 patients with acute craniocerebral injury, followed by immunohistochemical detection of the expression patterns of Forkhead box M1, anterior gradient 2, and hypoxia-inducible factor-1α.
[Laboratory Investigation]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Clinical Characterization and Immunosuppressive Regulation of CD161 (KLRB1) in Glioma through 916 Samples

Retrospective RNA-seq data analysis was conducted in a cohort of 313 patients with glioma in the Chinese Glioma Genome Atlas database and 603 patients in the TCGA database.
[Cancer Science]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Netrin-Like Domain of sFRP4, a Wnt Antagonist Inhibits Stemness, Metastatic and Invasive Properties by Specifically Blocking MMP-2 in Cancer Stem Cells from Human Glioma Cell Line U87MG

Researchers explored the efficacy of the domains of secreted frizzled-related protein 4 (sFRP4) in inhibiting the key hallmarks of glioblastoma such as invasion, metastasis, and stemness.
[Experimental Cell Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model

Researchers characterized the time-dependent impact of regadenoson on brain endothelial cell interactions and paracellular transport, using mouse and rat brain endothelial cells and tumor models.
[Molecular Cancer Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Cilium Induction Triggers Differentiation of Glioma Stem Cells

Scientists showed that patient-derived glioma stem cells recruited elevated levels of proteins that ensured the temporal cilium disassembly, leading to suppressed ciliogenesis.
[Cell Reports]
[zotpress userid=” items=’3ND5EQX2′ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Cilium Induction Triggers Differentiation of Glioma Stem Cells

Investigators showed that patient-derived glioma-stem cells recruited elevated levels of proteins that ensure the temporal cilium disassembly, leading to suppressed ciliogenesis.
[Cell Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

The Implications of Nitric Oxide Metabolism in the Treatment of Glial Tumors

The influence of nitric oxide and nitric oxide synthase (NOS) activity on glioma stem cells seem to be of particular importance. The use of specific inhibitors may allow the reduction of tumor growth and its tendency to relapse.
[Neurochemistry International]
[zotpress userid=” items=’P2JKVSKR’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Elucidating the Mechanisms of Temozolomide Resistance in Gliomas and the Strategies to Overcome the Resistance

Scientists summarize different strategies that intensify the temozolomide effect such as MGMT inhibition, development of novel imidazotetrazine analog, and combination therapy; with an aim to incorporate a successful treatment and increased overall survival in glioblastoma patients.
[Biochimica et Biophysica Acta-Reviews On Cancer]
[zotpress userid=” items=’YHSAEEG4′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Molecular Characterization of AEBP1 at Transcriptional Level in Glioma

Three datasets were used to perform the analysis to search for the key genes related to glioma stem cell, temozolomide resistance, and prognosis. The key gene for further research was selected by reviewing the previous studies.
[Biomed Research International]
[zotpress userid=” items=’Q5F6RAVE’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share