Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model

Researchers characterized the time-dependent impact of regadenoson on brain endothelial cell interactions and paracellular transport, using mouse and rat brain endothelial cells and tumor models.
[Molecular Cancer Research]
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Cilium Induction Triggers Differentiation of Glioma Stem Cells

Scientists showed that patient-derived glioma stem cells recruited elevated levels of proteins that ensured the temporal cilium disassembly, leading to suppressed ciliogenesis.
[Cell Reports]
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Cilium Induction Triggers Differentiation of Glioma Stem Cells

Investigators showed that patient-derived glioma-stem cells recruited elevated levels of proteins that ensure the temporal cilium disassembly, leading to suppressed ciliogenesis.
[Cell Reports]
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The Implications of Nitric Oxide Metabolism in the Treatment of Glial Tumors

The influence of nitric oxide and nitric oxide synthase (NOS) activity on glioma stem cells seem to be of particular importance. The use of specific inhibitors may allow the reduction of tumor growth and its tendency to relapse.
[Neurochemistry International]
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Elucidating the Mechanisms of Temozolomide Resistance in Gliomas and the Strategies to Overcome the Resistance

Scientists summarize different strategies that intensify the temozolomide effect such as MGMT inhibition, development of novel imidazotetrazine analog, and combination therapy; with an aim to incorporate a successful treatment and increased overall survival in glioblastoma patients.
[Biochimica et Biophysica Acta-Reviews On Cancer]
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Molecular Characterization of AEBP1 at Transcriptional Level in Glioma

Three datasets were used to perform the analysis to search for the key genes related to glioma stem cell, temozolomide resistance, and prognosis. The key gene for further research was selected by reviewing the previous studies.
[Biomed Research International]
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Elevated Cellular PpIX Potentiates Sonodynamic Therapy in a Mouse Glioma Stem Cell-Bearing Glioma Model by Downregulating the Akt/NF-κB/MDR1 Pathway

In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.
[Scientific Reports]
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Therapeutic Perspective of Temozolomide Resistance in Glioblastoma Treatment

The authors summarize the temozolomide (TMZ)-resistance mechanisms and discuss several potential therapies from conservative opinion of glioma stem cell-targeted therapy orientation to current view of TMZ resistance-aimed efficacy.
[Cancer Investigation]
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Glioma Stem Cell-Derived Exosomal miR-944 Reduces Glioma Growth and Angiogenesis by Inhibiting AKT/ERK Signaling

Scientists investigated the regulatory role of exosomal miR-944 derived from glioma stem cells in glioma progression and angiogenesis.
[Aging]
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Inhibiting DNA-Pk Induces Glioma Stem Cell Differentiation and Sensitizes Glioblastoma to Radiation in Mice

Scientists reported that DNA-dependent protein kinase (DNA-PK) governed SOX2 stability through phosphorylation, resulting in glioma stem cell maintenance.
[Science Translational Medicine]
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Dual Role of WNT5A in Promoting Endothelial Differentiation of Glioma Stem Cells and Angiogenesis of Glioma Derived Endothelial Cells

Researchers reported that wingless-related integration site family member 5A (WNT5A) played significant roles in glioma stem cell endothelial differentiation and glioma-derived endothelial cells’ angiogenesis.
[Oncogene]
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