In a hypoxic microenvironment the hypoxia-inducible factor 1α (HIF1α)/HIF2α-miR210-3p network promoted the malignant progression of glioblastoma through a positive feedback loop with epidermal growth factor (EGF).
[Cell Death & Disease]
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The HIF1α/HIF2α-miR210-3p network regulates glioblastoma cell proliferation, dedifferentiation and chemoresistance through EGF under hypoxic conditions | Cell Death & Disease. (n.d.). Retrieved November 18, 2020, from https://www.nature.com/articles/s41419-020-03150-0 Cite
Scientists explored the mechanisms by which lncRNA derived from hypoxic glioma stem cells cause glioma progression. Isolation and identification of the Linc01060 gene, the exosomes containing them, and the proteins from tumor cells regulating the gene allowed for studying the effects of Linc01060 on proliferation and glycometabolism.
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Li, J., Liao, T., Liu, H., Yuan, H., Ouyang, T., Wang, J., Chai, S., Li, J., Chen, J., Li, X., Zhao, H., & Xiong, N. (2020). Hypoxic glioma stem cell-derived exosomes containing Linc01060 promote progression of glioma by regulating the MZF1/c-Myc/HIF-1α. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2270 Cite
Researchers showed that the Special AT‐rich Binding Protein‐2 (SATB2), one of crucial NMPs, recruited histone acetyltransferase CBP to promote the FOXM1‐mediated cell proliferation and tumor growth of glioblastoma.
[EMBO Molecular Medicine]
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Tao, W., Zhang, A., Zhai, K., Huang, Z., Huang, H., Zhou, W., Huang, Q., Fang, X., Prager, B. C., Wang, X., Wu, Q., Sloan, A. E., Ahluwalia, M. S., Lathia, J. D., Yu, J. S., Rich, J. N., & Bao, S. (2020). SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells. EMBO Molecular Medicine, n/a(n/a), e12291. https://doi.org/10.15252/emmm.202012291 Cite
Researchers identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity. Silencing TNC decreased proliferation, migration and suppresses self-renewal of glioma stem cells.
Single-cell sequencing data from seven surgical specimens of glioblastoma patients and patient-derived glioma stem cells co-cultured with peripheral leukocytes were used for the analysis.
[Frontiers in Immunology]
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Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
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Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3 Cite
Researchers showed that epidermal growth factor receptor variant III (EGFRvIII) induced the expression of p-Src and PLK1, and both induced the Notch1-SOX2 signaling pathway to promote self-renewal and tumor progression of GSCs.
[Experimental Cell Research]
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Dual inhibition of Src and PLK1 regulate stemness and induce apoptosis through Notch1-SOX2 signaling in EGFRvIII positive glioma stem cells (GSCs) - ScienceDirect. (n.d.). Retrieved September 9, 2020, from https://www.sciencedirect.com/science/article/abs/pii/S0014482720305103?via%3Dihub Cite
Macrophage receptor with collagenous structurehigh TAMs induced a phenotypic shift towards mesenchymal cellular state of glioma stem cells, promoting both invasive and proliferative activities, as well as therapeutic resistance to irradiation.
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Sa, J. K., Chang, N., Lee, H. W., Cho, H. J., Ceccarelli, M., Cerulo, L., Yin, J., Kim, S. S., Caruso, F. P., Lee, M., Kim, D., Oh, Y. T., Lee, Y., Her, N.-G., Min, B., Kim, H.-J., Jeong, D. E., Kim, H.-M., Kim, H., … Nam, D.-H. (2020). Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma. Genome Biology, 21(1), 216. https://doi.org/10.1186/s13059-020-02140-x Cite
Infection of patient-derived glioma cells with adenovirus (ADV) increased the formation of tumor spheres. ADV infection upregulated stem cell markers and in turn promoted the capacities of self-renewal and multi-lineage differentiation of the infected tumor spheres.
[Cell Communication and Signaling]
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Investigators showed that the 2-nitroimidazole doranidazole potentiated radiation-induced DNA damage in hypoxic glioma stem cells (GSCs) and conferred a significant survival benefit in mice harboring GSC-derived tumors in radiotherapy settings.
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Scientists examined whether epidermal growth factor receptor (EGFR) signaling affects bone morphogenic protein 4-induced differentiation of glioma stem cells and their response to the alkylating drug temozolomide.
[Experimental and Molecular Medicine]
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