HOXA5 Is Amplified in Glioblastoma Stem Cells and Promotes Tumor Progression by Transcriptionally Activating PTPRZ1

Scientists identified the gene amplification and protein overexpression of HOXA5 in glioma stem cells (GSCs) and its function in regulating GSC maintenance and the downstream transcriptional effector, to explore the significance of HOXA5 amplification/overexpression for GSC identification and prognostic determination.