graft-versus-host disease

[Leukemia & Lymphoma] Investigators retrospectively analyzed 55 patients who underwent allogeneic stem cell transplantation for mantle cell lymphoma relapsed or refractory after rituximab and high-dose cytarabine within the MANTLE-FIRST project.

[Cellular & Molecular Immunology] The authors found that posttransplant treatment with the CXCR4 antagonist AMD3100 significantly improved the eradication of leukemia cells in the bone marrow in patient-derived xenograft mice grafted with B cell acute lymphoblastic leukemia cells from multiple patients.

[Blood] Scientists discuss the current approach to various linical issues and how emerging novel therapeutics hold promise to advance transplant care for patients with non-malignant diseases.

[European Journal of Haematology] Scientists analyzed the outcomes of 483 patients who received hematopoietic stem cell transplantation between August 2017 and August 2020 in a retrospective study, comparing the outcomes between those who received cryopreserved or fresh peripheral blood stem cell grafts.

[Bone Marrow Transplantation] Scientists presented the results of a prospective non-interventional study performed by the EBMT on 383 consecutive chronic myeloid leukemia patients previously treated with dasatinib or nilotinib undergoing allogeneic hematopoietic cell transplantation from 2009 to 2013.

[Annals of Hematology] Scientists evaluated the efficacy and safety of venetoclax plus azacitidine and donor lymphocyte infusion in treating patients with relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation.