hematopoietic stem cells

[AlloVir, Inc.] AlloVir, Inc. announced that the US FDA has granted its lead multi-virus specific T cell therapy, posoleucel, RMAT designation for the treatment of AdV infection following allogeneic hematopoietic stem cell transplant. The designation is based on positive results from the Phase II CHARMS study.

[Science Advances] Investigators used single-cell full-length transcriptome data to construct an isoform-based transcriptional atlas of the murine endothelial-to-HSC transition, which enabled the identification of hemogenic signature isoforms and stage-specific alternative splicing events.

[Blood] Scientists reported the first large-scale genome-wide association study on blood CD34+ cell levels. Across 13,167 individuals, they identified 9 significant and 2 suggestive associations, accounted for by 8 loci.

[Journal of Nanobiotechnology] Researchers investigated the effects of exosomes derived from bone marrow mesenchymal stem cells on the regulation of acute myeloid leukemia and the underlying mechanisms mediated by microRNA.

[Cancer Gene Therapy] Scientists discuss different generations, challenges, and clinical studies related to chimeric antigen receptor (CAR) T cells for ALL treatment.

[Stem Cell Reviews and Reports] Investigators proposed a 3D environment based on gallic acid grafted-chitosan scaffold and osteoblasts differentiated from human umbilical cord mesenchymal stem cells to recapitulate the main components of hematopoietic stem cells niche.