hematopoietic stem cells

[Scientific Reports] Scientists found that cytokine-specific autoantibodies (c-aAb) levels were stable over the course of hematopoietic stem cell transplantation, including at high titres, with few individuals seeming to acquire high-titre levels of c-aAbs.

[CoImmune, Inc.] CoImmune, Inc. announced that results from a Phase I/II clinical trial evaluating CARCIK-CD19, an investigational treatment based on the company’s chimeric antigen receptor modified cytokine induced killer cell platform, demonstrated sustained responses in pediatric and adult patients with B-cell acute lymphoblastic leukemia who had relapsed after allogeneic hematopoietic stem cell transplantation.

[iScience] The authors showed that cultured HSCs expressed mast cell-related genes including Cd244 and suggested CD244 was a potent marker to exclude non-functional HSCs after in vitro culture thereby useful to elucidate mechanism of functional decline of HSCs during ex vivo treatment.

[Scientific Reports] Researchers established inducible P18/hESC lines and monitored the effects of P18 overexpression on hematopoietic differentiation and found evidence that P18 promoted hematopoiesis, a rare property among cyclin-dependent kinase inhibitors.

[Science Advances] Scientists described conditionally pathogenic enhancer motif variants that differentially affected hematopoietic development and regeneration. Despite normal developmental hematopoiesis, regeneration in response to chemotherapy, inflammation, and a therapeutic HSC mobilizer was compromised.

[Cell Reports] Investigators showed that in Ncx1−/− mouse embryos devoid of circulation, the HSC lineage developed until the phenotypic pro-HSC stage. Experimental activation of glycolysis resulted in decreased intraembryonic hematopoiesis, suggesting that the onset of circulation triggered metabolic changes that allowed HSC generation to proceed.