hematopoietic stem cells

[Transfusion] A protocol was developed for the collection of small volume pediatric whole blood via peripheral venipuncture with collection into 10 ml syringes containing anticoagulants.

[Bone Marrow Transplantation] Scientists analyzed available literature on the role of allogeneic hematopoietic stem cell transplant in adolescent and adult patients using PubMed, Cochrane, Embase and ClinicalTrials.gov.

[International Journal of Hematology] Scientists investigated the optimal timing and cutoff value to ascertain the value of NPM1 mutation in measurable residual disease assessment.

[US FDA] The FDA approved axicabtagene ciloleucel for adult patients with large B-cell lymphoma that is refractory to first-line chemoimmunotherapy or relapses within 12 months of first-line chemoimmunotherapy.

[Nature Communications] To identify the signals responsible for HSC formation, scientists used single cell RNA-sequencing to simultaneously analyze the transcriptional profiles of aorta-gonad-mesonephros region-derived cells transitioning from hemogenic endothelium to HSCs,

[Stem Cell Reviews and Reports] Scientists found that pharmacological inhibition of NF-κB pathway in both control and CoCl2-treated mesenchymal stromal cells completely blocked their intercellular communication with the co-cultured HSCs and progenitor cells, resulting in an extremely poor output of hematopoietic cells.