Humanigen Announces Clinical Trial Collaboration to Evaluate Lenzilumab in Acute Graft versus Host Disease

Humanigen, Inc. announced it plans to support a Phase II/III study to evaluate lenzilumab for the early treatment of acute graft versus host disease following allogeneic hematopoietic stem cell transplantation in collaboration with IMPACT.
[Humanigen, Inc.]
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Resistance to Inflammation Underlies Enhanced Fitness in Clonal Hematopoiesis

Researchers developed a technique that combines mosaic mutagenesis with color labeling of hematopoietic stem and progenitor cells to study how acquired mutations affect clonal fitness in a native environment.
[Science]
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The GPI-Anchored Protein CD109 Protects Hematopoietic Progenitor Cells from Undergoing Erythroid Differentiation Induced by TGF-β

Investigators found that CD109 suppressed TGF-β signaling in hematopoietic stem progenitor cells (HSPCs), and increased the sensitivity of PIGA-mutated HSPCs to TGF-β, leading to the preferential commitment of erythroid progenitor cells to mature red blood cells in immune-mediated bone marrow failure.
[Leukemia]
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Jasper Therapeutics Announces Research Collaboration with AVROBIO to Evaluate JSP191 as Conditioning Agent in Clinical Studies of Ex Vivo Lentiviral Gene Therapy

Jasper Therapeutics, Inc. announced that it has entered into a non-exclusive research collaboration with AVROBIO, Inc. to evaluate the use of JSP191, Jasper’s anti-CD117 monoclonal antibody, as a targeted conditioning agent option for patients with Fabry disease and/or Gaucher disease type 1.
[Jasper Therapeutics, Inc.]
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EdiGene Enters Research Collaboration with the University of Wisconsin-Madison on In Vivo RNA Editing Therapies

EdiGene, Inc. has entered into a research collaboration with the University of Wisconsin–Madison as part of the company’s effort of translating proprietary LEAPER RNA editing technology into in vivo therapies.
[EdiGene, Inc.]
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Hypoxia Preconditioned Mesenchymal Stem Cell-Derived Exosomes Induce Ex Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells CD133+ by Stimulation of Notch Signalling Pathway

Scientists examined the importance of hypoxia-preconditioned mesenchymal stem cells-derived exosomes and normoxia-preconditioned MSC-derived exosomes in the self-renewal and long-term clonogenic potential of umbilical cord blood hematopoietic stem cells.
[Biotechnology Progress]
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Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow

Scientists review recent literature on energy production in glioblastoma stem cells and leukemic stem cells versus their normal counterparts, neural stem cells and hematopoietic stem cells, respectively.
[Journal of Histochemistry & Cytochemistry]
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Umbilical Cord Blood Transplantation after Graft Failure from a Previous Hematopoietic Stem Cell Transplantation

Researchers described an umbilical cord blood transplants performed after graft failure following a previous hematopoietic stem cell transplantation.
[American Society for Transplantation and Cellular Therapy]
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The Possible Role of Mutated Endothelial Cells in Myeloproliferative Neoplasms

Researchers reviewed the numerous studies performed during the last decade identifying endothelial cell dysregulation as a factor contributing to myeloproliferative neoplasms disease development.
[Haematologica]
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TGFβ Signaling Modifies Hematopoietic Acute Inflammatory Response to Drive Bone Marrow Failure

Scientists examined the effect of increased TGFβ signaling in combination or not with an acute innate immune challenge using polyinosinc:polycytidilic acid on the hematopoietic system without genetic mutations.
[Haematologica]
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CITED2 Coordinates Key Hematopoietic Regulatory Pathways to Maintain the HSC Pool in Both Steady-State Hematopoiesis and Transplantation

While hematopoietic-specific Cited2 deletion has a minor impact on steady-state hematopoiesis, Cited2-deficient hematopoietic stem cells are severely depleted in young mice and fail to expand upon aging.
[Stem Cell Reports]
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