Following Treg depletion, the function and phenotype of both MSCs and hematopoietic stem cells was impaired. Transplantation also revealed that a Treg-depleted niche had a reduced capacity to support hematopoiesis.
6630899 3RK4WYBA items 1 apa default asc 1
Camacho, V., Matkins, V. R., Patel, S. B., Lever, J. M., Yang, Z., Ying, L., Landuyt, A. E., Dean, E. C., George, J. F., Yang, H., Ferrell, P. B., Maynard, C. L., Weaver, C. T., Turnquist, H. R., & Welner, R. S. (2020). Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10. JCI Insight, 5(22). https://doi.org/10.1172/jci.insight.135681 Cite
Orchard Therapeutics announced that the FDA has cleared the company’s Investigational New Drug application for OTL-200, an autologous, hematopoietic stem cell, lentiviral vector-based gene therapy in development for the treatment of MLD.
1254621 nan items 1 apa default asc 1
CD34‐CD42b platelet‐targeting bispecific antibodies were designed to simultaneously recognize HSCs and platelets. After inhalation delivery, PT‐BsAbs reached the lungs and conjoined HSCs and platelets.
6445218 PM9FTKYZ items 1 apa default asc 1
Liu, M., Lutz, H., Zhu, D., Huang, K., Li, Z., Dinh, P.-U. C., Gao, J., Zhang, Y., & Cheng, K. (n.d.). Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury. Advanced Science, n/a(n/a), 2002127. https://doi.org/https://doi.org/10.1002/advs.202002127 Cite
Using a murine model of malaria and combining single-cell RNA sequencing, mathematical modelling, transplantation assays and intravital microscopy, researchers showed that haematopoiesis was reprogrammed upon infection.
[Nature Cell Biology]
6445218 6LKPWTJU items 1 apa default asc 1
Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection | Nature Cell Biology. (n.d.). Retrieved November 24, 2020, from https://www.nature.com/articles/s41556-020-00601-w Cite
To investigate the role of nucleotide-binding oligomerization domain-like receptors in neutrophil homeostasis, researchers used Nlrp6 gene-deficient mice in a model of Klebsiella pneumoniae-induced pneumonia-derived sepsis.
6445218 9NX4WXYH items 1 apa default asc 1
Using a murine model of malaria and combining single-cell RNA sequencing, mathematical modelling, transplantation assays and intravital microscopy, scientists showed that hematopoiesis was reprogrammed upon infection, whereby the hematopoietic stem cell (HCS) compartment turned over substantially faster than at steady-state and HSC function was drastically affected.
[Nature Cell Biology]
1254621 YL4TCI4Z items 1 apa default asc 1
Investigators prospectively measured insulin-like growth factor-l (IGF-l) concentrations in 121 pediatric patients before, during, and after allogeneic hematopoietic stem cell transplantatio. Overall, IGF-l levels were significantly reduced compared with healthy sex- and age-matched children.
[Bone Marrow Transplantation]
6445212 MPNMTU7N items 1 apa default asc 1
Ebbesen, M., Weischendorff, S., Kielsen, K., Kammersgaard, M., Juul, A., & Müller, K. G. (2020). Insulin-like growth factor-I predicts sinusoidal obstruction syndrome following pediatric hematopoietic stem cell transplantation. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01127-3 Cite
The authors evaluate evidence for a layered hematopoietic system across species. They discuss mechanisms and selective pressures leading to the temporal generation of different cell types.
[Frontiers in Cell and Developmental Biology]
6445212 HX4N3DAR items 1 apa default asc 1
One promising alternative can be human pluripotent stem cells (PSCs) that provide an unlimited source of cells. Human PSCs, including embryonic stem cells and induced pluripotent stem cells, are self-renewing progenitors that can be differentiated to lineages of ectoderm, mesoderm, and endoderm.
[Stem Cell Research & Therapy]
6445212 nan items 1 apa default asc 1
Investigators review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of allogeneic hematopoietic stem cell transplantation, from the hematopoietic stem cell (HSC) mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC infusion.
[Cellular & Molecular Immunology]
Investigators tested the use of low-dose memory donor lymphocyte infusion after engraftment of αβ T cell-depleted grafts. A cohort of 131 pediatric patients were grafted with αβ T cell-depleted products from either haplo or unrelated donors.
[Bone Marrow Transplantation]
6445212 /VVCTV6ZR items 1 apa default asc 1
Blagov, S., Zvyagin, I. V., Shelikhova, L., Khismatullina, R., Balashov, D., Komech, E., Fomchenkova, V., Shugay, M., Starichkova, J., Kurnikova, E., Pershin, D., Fadeeva, M., Glushkova, S., Muzalevskii, Y., Kazachenok, A., Efimenko, M., Osipova, E., Novichkova, G., Chudakov, D., … Maschan, M. (2020). T-cell tracking, safety, and effect of low-dose donor memory T-cell infusions after αβ T cell-depleted hematopoietic stem cell transplantation. Bone Marrow Transplantation, 1–9. https://doi.org/10.1038/s41409-020-01128-2 Cite