hematopoietic stem cells

[EdiGene, Inc.] EdiGene, Inc. has entered into a research collaboration with the University of Wisconsin–Madison as part of the company’s effort of translating proprietary LEAPER™ RNA editing technology into in vivo therapies.

[Science] Researchers developed a technique that combines mosaic mutagenesis with color labeling of hematopoietic stem and progenitor cells to study how acquired mutations affect clonal fitness in a native environment.

[Leukemia] Investigators found that CD109 suppressed TGF-β signaling in hematopoietic stem progenitor cells (HSPCs), and increased the sensitivity of PIGA-mutated HSPCs to TGF-β, leading to the preferential commitment of erythroid progenitor cells to mature red blood cells in immune-mediated bone marrow failure.

[Jasper Therapeutics, Inc.] Jasper Therapeutics, Inc. announced that it has entered into a non-exclusive research collaboration with AVROBIO, Inc. to evaluate the use of JSP191, Jasper's anti-CD117 monoclonal antibody, as a targeted conditioning agent option for patients with Fabry disease and/or Gaucher disease type 1.

[Biotechnology Progress] Scientists examined the importance of hypoxia-preconditioned mesenchymal stem cells-derived exosomes and normoxia-preconditioned MSC-derived exosomes in the self-renewal and long-term clonogenic potential of umbilical cord blood hematopoietic stem cells.

[Haematologica] Scientists examined the effect of increased TGFβ signaling in combination or not with an acute innate immune challenge using polyinosinc:polycytidilic acid on the hematopoietic system without genetic mutations.