hematopoietic stem cells

[Journal of Experimental & Clinical Cancer Research] Alloantigen-activated CD4+ T cells were generated from CD4+ T cells isolated from BALB/c mice in cultures with dendritic cells induced from C57BL/6 mice.

[JCI Insight] Scientists identified a tumor suppressor role of the acetyltransferase p300 in clinically relevant myelodysplastic syndromes models driven by mutations in the epigenetic regulators TET2, ASXL1, and SRSF2.

[British Journal of Haematology] Scientists focus on the immune landscape in patients with myeloproliferative neoplasms – the role of inflammation in disease pathogenesis, susceptibility to infection and emerging strategies for therapeutic immune modulation.

[Cell Death & Disease] Investigators characterized a zebrafish smu471 mutant with hematopoietic stem/progenitor cell defects and found that sart3 was the causative gene.

[Leukemia] The authors developed a zebrafish tet2 mutant through which they showed that tet2 loss led to restricted hematopoietic differentiation combined with a modest upregulation of p53, which was also characteristic of many inherited bone marrow failure syndromes.

[Blood Advances] Investigators conducted a multicenter, open-label, Phase II, single-arm study of pembrolizumab in patients with DIPSS intermediate 2 or greater primary, post-essential thrombocythemia or post-polycythemia vera myelofibrosis that were ineligible for or were previously treated with ruxolitinib.