hematopoietic stem cells

[Blood Advances] Through a combination of gene expression analysis in prospectively isolated non-hematopoietic bone marrow (BM) cell populations and various mouse models, the authors revealed that BM CXCL12-abundant reticular cells were a major source of systemic and local BM IL-6 levels during emergency hematopoiesis following lipopolysaccharide stimulation.

[Annals of Hematology] Scientists evaluated the efficacy and safety of venetoclax plus azacitidine and donor lymphocyte infusion in treating patients with relapsed acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation.

[Leukemia] Spred1 knockout, regardless if occurred in HSCs or in endothelial cells, increased miR-126 in Lin−Sca-1+c-Kit+, a population enriched in leukemic stem cells (LSCs), resulting in expansion of LSCs, likely through hyperactivation of the MAPK/ERK pathway that augmented Bcl-2 expression and stability.

[Cell Death & Disease] Scientists show that combining TKI treatment with the small-molecule MCL1 inhibitor S63845 exerted strong synergistic antiviability and proapoptotic effects on chronic myeloid leukemia (CML) lines and CD34+ stem/progenitor cells isolated from untreated CML patients in chronic phase.

[Science Translational Medicine] Disruption of the super-enhancer-associated gene transcription by THZ1, a covalent cyclin-dependent kinase 7 inhibitor, efficiently eradicated leukemia stem cells in retroviral BCR-ABL–driven chronic myelogenous leukemia mice while sparing normal hematopoietic stem cells.

[Blood] The authors reported that post-transcriptional repression of the transcription factor ARID3A by miR-125b was a key event in megakaryoblastic leukemia pathogenesis, and showed that chromosome 21-encoded miR-125b synergized with Gata1s to drive leukemogenesis in this context.