Super-Enhancer Landscape Reveals Leukemia Stem Cell Reliance on X-box Binding Protein 1 as a Therapeutic Vulnerability

Disruption of the super-enhancer-associated gene transcription by THZ1, a covalent cyclin-dependent kinase 7 inhibitor, efficiently eradicated leukemia stem cells in retroviral BCR-ABL–driven chronic myelogenous leukemia mice while sparing normal hematopoietic stem cells.