hematopoietic stem cells

[Blood] Researchers examined global alternative polyadenylation dysregulation in acute myeloid leukemia (AML) patients by performing 3' Region Extraction And Deep Sequencing on a subset of AML patient samples along with healthy hematopoietic stem and progenitor cells and by analyzing publicly available data from a broad AML patient cohort.

[Blood] Scientists summarize current advances and knowledge of long non-coding RNAs (lncRNAs) in gene regulation, focusing on the recent progresses on the role of lncRNAs in CTCF/cohesin mediated 3D genome organization, and how such genome folding signals in turn regulate transcription, hematopoietic stem and progenitor cell function and transformation.

[Science Advances] Researchers reported that INTS11 was required for normal hematopoiesis and hematopoietic-specific genetic deletion of Ints11 led to cell cycle arrest and impairment of fetal and adult hematopoietic stem and progenitor cells.

[Cell Stem Cell] Hematopoietic progenitor cells with biallelic frameshift and R525H mutations underwent cell cycle arrest and apoptosis, causing bone marrow failure in mice. Mechanistically, DDX41 was essential for small nucleolar RNA (snoRNA) processing, ribosome assembly, and protein synthesis.

[eLife] Using a Thpo translational reporter, researchers found that the liver but not the bone marrow was the major source of thrombopoietin protein after myeloablation. Mice with conditional Thpo deletion from hepatocytes showed significant defects in hematopoietic stem cell regeneration and hematopoietic rebound after myeloablation.

[Cytotherapy] Researchers highlighted the importance of regional public cord blood banks in fulfilling hematopoietic stem cell transplantation needs, especially in countries with significant genetic diversity.